Extreme Low Frequency Electromagnetic Field Stimulation Induces Metaplastic-Like Effects on LTP/ LTD
Extreme Low Frequency Electromagnetic Field Stimulation Induces Metaplastic-Like Effects on LTP/ LTD
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极低频电磁场刺激对 LTP/LTD 产生类化生效应
DOI：
10.1109/access.2019.2947690
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发表时间：
2019-10
期刊：
影响因子：
3.9
通讯作者：
Li Chengshuang
中科院分区：
文献类型：
--
作者：
Zheng Yu;Tian Chunxiao;Dong Lei;Ma Xiaoxu;Gao Yang;Xiong Chan;Zhang Anghui;Li Chengshuang
在现代社会中，人们更有可能接触到发射极低频（ELF，<300 Hz）电磁场（EMF）的技术设备。虽然ELF-EMF被成功地用作精神病学治疗和康复实践中的治疗剂，但它们也被认为是对人类健康构成风险的环境污染物。然而，一些研究表明，ELF-EMFs刺激有可能改善人类的学习和记忆过程。鉴于磁刺激对大脑的潜在机制尚未完全了解，本研究旨在研究极低频电磁场对学习和记忆形成的影响。以Sprague-Dawley大鼠为模型系统，采用ELF-EMF刺激，基于海马脑片中Schaffer-CA 1通路的突触可塑性来评估学习和记忆机制。基于先前的实验选择参数（即，15赫兹[Hz]，2毫特斯拉[mT]），在可塑性诱导期间和之后，施加1，5，20和100 Hz的基频，并一起使用在线ELF-EMFs刺激驱动，其先前定义为前，中和后刺激。我们的研究结果表明，最大的影响突触可塑性时，ELF-EMFs与可塑性诱导协议配对观察。重要的是，ELF-EMF不影响弱活性突触或含有被阻断的N-甲基-D-天冬氨酸（NMDA）受体的突触。本研究强调了ELF-EMFs的类化生作用，作为突触活动过程的调节剂，以及它们通过NMDA受体依赖性突触可塑性的调节。
In modern societies, people are more likely to be exposed to technological devices that emit extreme low frequency (ELF, <300 Hz)-electromagnetic fields (EMFs). Although ELF-EMFs are successfully used as therapeutic agents in psychiatry treatment and rehabilitation practices, they are also considered to be environmental pollutants that pose a risk to human health. However, several studies have suggested that ELF-EMFs stimulation has the potential to ameliorate learning and memory processes in humans. Given that the underlying mechanisms of magnetic stimulation on the brain are not fully understood, this study aimed to investigate the effects of ELF-EMFs in learning and memory formation. Sprague-Dawley rats were used as a model system to evaluate learning and memory mechanisms based on the synaptic plasticity of the Schaffer-CA1 pathway in hippocampal slices using ELF-EMFs stimulation. Parameters were selected based on previous experiments (i.e., 15 hertz [Hz], 2 militesla [mT]), during, and after plasticity induction, basic frequencies of 1, 5, 20 and 100 Hz were applied and an on-line ELF-EMFs stimulation drive was used together, which previously defined as preceding, middle and post stimulation. Our results showed that the greatest effect on synaptic plasticity was observed when ELF-EMFs were paired with a plasticity induction protocol. Importantly, ELF-EMFs did not affect synapses that were weakly active or in synapses containing N-methyl-D-aspartate (NMDA) receptors that were blocked. This study highlights the metaplastic-like role of ELF-EMFs, acting as modulators of synaptic activity processes,as well as their regulation by NMDA receptor-dependent synaptic plasticity.
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影响因子：
2.7
作者：
Jadidi, Majid;Firoozabadi, Seyed Mohammad;Taherian, Abbas Ali
通讯作者：
Taherian, Abbas Ali
DOI：
10.1063/1.5006520
发表时间：
2017-10
期刊：
The Review of scientific instruments
影响因子：
--
作者：
Yu Zheng;Wei-Ying Ma;Lei Dong;J. Dou;Yang Gao;Jing Xue
通讯作者：
Yu Zheng;Wei-Ying Ma;Lei Dong;J. Dou;Yang Gao;Jing Xue
影响因子：
2.9
作者：
Komaki, Alireza;Khalili, Afshin;Sarihi, Abdolrahman
通讯作者：
Sarihi, Abdolrahman
影响因子：
--
作者：
D. Long
通讯作者：
D. Long
影响因子：
5.3
作者：
Cuccurazzu, Bruna;Leone, Lucia;Grassi, Claudio
通讯作者：
Grassi, Claudio