H5N1 influenza viruses: outbreaks and biological properties.
H5N1 influenza viruses: outbreaks and biological properties.
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作者：
所有已知的甲型流感病毒亚型都存在于野生水禽中，野生水禽是这些病毒的天然宿主。甲型流感病毒分离自各种动物物种，具有不同的发病率和死亡率。更重要的是，甲型流感病毒会导致人类呼吸道疾病，并可能导致致命后果。人类局部或全球疫情的典型特征是过度住院和死亡。1997年，H5N1亚型的高致病性禽流感病毒在香港出现，并传播给人类，导致首次有记录的人类因感染禽流感病毒而死亡的病例。2003年7月在越南、印度尼西亚和泰国的家禽中开始了新的暴发，高致病性禽H5N1流感病毒此后蔓延到整个亚洲并进入欧洲和非洲。这些病毒继续以高死亡率感染人类，并引起全世界对即将到来的大流行病的关注。此外，H5N1病毒的爆发对整个亚洲的家禽业造成了毁灭性的影响。由于H5N1病毒暴发似乎起源于中国南方，我们在这里检查H5N1流感病毒在中国，重点是它们的生物学特性。
All known subtypes of influenza A viruses are maintained in wild waterfowl, the natural reservoir of these viruses. Influenza A viruses are isolated from a variety of animal species with varying morbidity and mortality rates. More importantly, influenza A viruses cause respiratory disease in humans with potentially fatal outcome. Local or global outbreaks in humans are typically characterized by excess hospitalizations and deaths. In 1997, highly pathogenic avian influenza viruses of the H5N1 subtype emerged in Hong Kong that transmitted to humans, resulting in the first documented cases of human death by avian influenza virus infection. A new outbreak started in July 2003 in poultry in Vietnam, Indonesia, and Thailand, and highly pathogenic avian H5N1 influenza viruses have since spread throughout Asia and into Europe and Africa. These viruses continue to infect humans with a high mortality rate and cause worldwide concern of a looming pandemic. Moreover, H5N1 virus outbreaks have had devastating effects on the poultry industries throughout Asia. Since H5N1 virus outbreaks appear to originate from Southern China, we here examine H5N1 influenza viruses in China, with an emphasis on their biological properties.
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影响因子：
5.4
作者：
Chin, PS;Hoffmann, E;Shortridge, KF
通讯作者：
Shortridge, KF
影响因子：
5.4
作者：
Cheung, C. L.;Vijaykrishna, D.;Guan, Y.
通讯作者：
Guan, Y.
影响因子：
168.9
作者：
Claas, ECJ;Osterhaus, ADME;Webster, RG
通讯作者：
Webster, RG
影响因子：
3.7
作者：
Gambaryan, A;Tuzikov, A;Klimov, A
通讯作者：
Klimov, A
DOI：
10.1073/pnas.0511120103
发表时间：
2006-02-21
影响因子：
11.1
作者：
Chen, H;Smith, GJD;Guan, Y
通讯作者：
Guan, Y