Subthreshold repetitive transcranial magnetic stimulation suppresses ketamine-induced poly population spikes in rat sensorimotor cortex.
Subthreshold repetitive transcranial magnetic stimulation suppresses ketamine-induced poly population spikes in rat sensorimotor cortex.
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阈下重复经颅磁刺激可抑制氯胺酮诱导的大鼠感觉运动皮层多群峰电位。
DOI：
10.3389/fnins.2022.998704
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发表时间：
2022
影响因子：
4.3
通讯作者：
Song, Dong
中科院分区：
文献类型：
--
作者：
Jiang, Wenxuan;Isenhart, Robert;Sutherland, Robert;Lu, Zhouxiao;Xu, Huijing;Pace, John;Bonaguidi, Michael A.;Lee, Darrin J.;Liu, Charles Y.;Song, Dong
大脑区域内或跨大脑区域的皮层振荡在感觉、运动和记忆功能中起着重要作用。它可以通过神经调节（如重复经颅磁刺激（rTMS））和药物操作（如氯胺酮）来改变。然而，rTMS和氯胺酮的影响，以及它们的相互作用，对皮层振荡的神经生物学基础还不清楚。在这项研究中，我们开发并应用了一种啮齿动物模型，能够同时进行rTMS治疗，药理学操作和侵入性电生理记录，这在人类中是困难的。具体而言，一个小型化的C形线圈的设计和制造提供局灶性阈下rTMS以上的初级躯体感觉（S1）和运动（M1）皮层大鼠。植入多电极阵列（MEA）以记录局部场电位（LFP）和单个单元活动。一种新的同步活动形式，多群体尖峰（PPS），被发现作为LFPs中氯胺酮的生物标志物。短暂的阈下rTMS有效且可逆地抑制PPS，同时增加单个单位活动的放电率。这些结果表明，氯胺酮和rTMS有收敛，但对皮层振荡和电路相反的影响。这种高度稳健的现象对于理解rTMS和氯胺酮的神经生物学机制以及开发涉及神经调节和药理学试剂的新治疗策略具有重要意义。
Cortical oscillations within or across brain regions play fundamental roles in sensory, motor, and memory functions. It can be altered by neuromodulations such as repetitive transcranial magnetic stimulation (rTMS) and pharmacological manipulations such as ketamine. However, the neurobiological basis of the effects of rTMS and ketamine, as well as their interactions, on cortical oscillations is not understood. In this study, we developed and applied a rodent model that enabled simultaneous rTMS treatment, pharmacological manipulations, and invasive electrophysiological recordings, which is difficult in humans. Specifically, a miniaturized C-shaped coil was designed and fabricated to deliver focal subthreshold rTMS above the primary somatosensory (S1) and motor (M1) cortex in rats. Multi-electrode arrays (MEA) were implanted to record local field potentials (LFPs) and single unit activities. A novel form of synchronized activities, poly population spikes (PPS), was discovered as the biomarker of ketamine in LFPs. Brief subthreshold rTMS effectively and reversibly suppressed PPS while increasing the firing rates of single unit activities. These results suggest that ketamine and rTMS have convergent but opposing effects on cortical oscillations and circuits. This highly robust phenomenon has important implications to understanding the neurobiological mechanisms of rTMS and ketamine as well as developing new therapeutic strategies involving both neuromodulation and pharmacological agents.
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影响因子：
3.6
作者：
Avoli, Massimo;Biagini, Giuseppe;de Curtis, M
通讯作者：
de Curtis, M
影响因子：
4.3
作者：
Dubin, Marc J.;Mao, Xiangling;Shungu, Dikoma C.
通讯作者：
Shungu, Dikoma C.
DOI：
10.1523/jneurosci.2339-11.2011
发表时间：
2011-10-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chauvette S;Crochet S;Volgushev M;Timofeev I
通讯作者：
Timofeev I
影响因子：
2.2
作者：
Best, Steven Richard Devore;Griffin, Brian
通讯作者：
Griffin, Brian
影响因子：
4.8
作者：
Herbsman, Tal;Forster, Lauren;Molnar, Christine;Dougherty, Robert;Christie, Doug;Koola, Jejo;Ramsey, Dave;Morgan, Paul S.;Bohning, Daryl E.;George, Mark S.;Nahas, Ziad
通讯作者：
Nahas, Ziad