Is mate choice in humans MHC-dependent?
Is mate choice in humans MHC-dependent?
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DOI：
10.1371/journal.pgen.1000184
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发表时间：
2008-09-12
期刊：
影响因子：
4.5
通讯作者：
Donnelly, Peter
中科院分区：
文献类型：
--
作者：
Chaix, Raphaelle;Cao, Chen;Donnelly, Peter
在包括啮齿动物和鱼类在内的几个物种中，已表明主要组织相容性复合体（MHC）影响交配偏好，在某些情况下，这可能是由基于体味的偏好介导的。在人类中，情况就不那么清楚了。一些研究报告了人类倾向于选择MHC不相似的配偶，这种性选择有利于产生MHC杂合后代，这些后代对病原体更具抵抗力，但这些结果没有得到其他研究的支持。在这里，我们报告了全基因组基因型数据（来自HapMap II数据集）和非洲和欧洲美国夫妇的HLA类型的分析，以测试人类是否倾向于选择MHC不相似的配偶。为了区分MHC特异性效应和全基因组效应，将MHC区域的相似性模式与基因组其余部分的模式进行比较。非洲配偶在整个MHC区域没有表现出显著的相似性/不相似性模式（相关系数，R = 0.015，p = 0.23），而在整个基因组中，他们比随机配对的个体更相似（全基因组R = 0.00185，p<10−3）。 我们讨论了这些观察结果的几种解释，包括人口效应。另一方面，与随机配对的个体相比，抽样的欧美夫妇的MHC不相似性显著更高（R =-0.043，p = 0.015），并且与基因组的其他部分相比，这种不相似性的模式是极端的，无论是在全球范围内（全基因组R =-0.00016，p = 0.739）还是当分解成具有与MHC相同长度和重组率的窗口时（只有9个基因组区域显示出配偶之间比MHC更高的遗传不相似性）。 因此，这项研究支持了MHC影响某些人群择偶的假设。有一个长期存在的假设，选择可能导致交配模式，鼓励杂合性在主要组织相容性复合体（MHC）基因座，因为改善免疫反应的病原体在这样的交配的后代，而且，事实上，这已经观察到在几个模型系统。然而，在人类中，先前关于MHC在配偶选择或偏好中的作用的研究，无论是直接在夫妇中还是间接在“汗湿T恤”实验中，都报告了相互矛盾的结果。在这里，通过使用全基因组基因型数据和HLA类型的非洲和欧洲的美国夫妇，我们测试人类是否倾向于选择MHC不同的伴侣。这种方法使我们能够区分MHC特异性效应和全基因组效应。在非洲样本中，MHC基因座的模式受到全基因组效应的混淆，可能是由于与该人群的社会组织相关的人口统计过程，并且没有检测到选择MHC不同配偶的倾向。另一方面，抽样的欧洲裔美国人似乎更喜欢MHC不同的配偶，这支持了MHC影响某些人群择偶的假设。因此，这项研究表明，在某些情况下，人类在选择伴侣时，除了社会因素外，还可能依赖生物因素。
In several species, including rodents and fish, it has been shown that the Major Histocompatibility Complex (MHC) influences mating preferences and, in some cases, that this may be mediated by preferences based on body odour. In humans, the picture has been less clear. Several studies have reported a tendency for humans to prefer MHC-dissimilar mates, a sexual selection that would favour the production of MHC-heterozygous offspring, who would be more resistant to pathogens, but these results are unsupported by other studies. Here, we report analyses of genome-wide genotype data (from the HapMap II dataset) and HLA types in African and European American couples to test whether humans tend to choose MHC-dissimilar mates. In order to distinguish MHC-specific effects from genome-wide effects, the pattern of similarity in the MHC region is compared to the pattern in the rest of the genome. African spouses show no significant pattern of similarity/dissimilarity across the MHC region (relatedness coefficient, R = 0.015, p = 0.23), whereas across the genome, they are more similar than random pairs of individuals (genome-wide R = 0.00185, p<10−3). We discuss several explanations for these observations, including demographic effects. On the other hand, the sampled European American couples are significantly more MHC-dissimilar than random pairs of individuals (R = −0.043, p = 0.015), and this pattern of dissimilarity is extreme when compared to the rest of the genome, both globally (genome-wide R = −0.00016, p = 0.739) and when broken into windows having the same length and recombination rate as the MHC (only nine genomic regions exhibit a higher level of genetic dissimilarity between spouses than does the MHC). This study thus supports the hypothesis that the MHC influences mate choice in some human populations. There has been a longstanding hypothesis that selection may have led to mating patterns that encourage heterozygosity at Major Histocompatibility Complex (MHC) loci because of improved immune response to pathogens in the offspring of such matings, and, indeed, this has been observed in several model systems. However, in humans, previous studies regarding the role of the MHC in mate choice or preference, both directly in couples and also indirectly in “sweaty T-shirts” experiments, have reported conflicting results. Here, by using genome-wide genotype data and HLA types in African and European American couples, we test whether humans tend to choose MHC-dissimilar mates. This approach allows us to distinguish MHC-specific effects from genome-wide effects. In the African sample, the patterns at MHC loci is confounded by genome-wide effects, possibly resulting from demographic processes relating to the social organization of this population, and no tendency to choose MHC-dissimilar mates is detected. On the other hand, the sampled European Americans appear to have favoured MHC-dissimilar mates, supporting the hypothesis that MHC influences mate choice in some human populations. Thus, this study suggests that, in some cases, humans may rely on biological factors, in addition to social factors, when choosing a mate.
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影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
2.5
作者：
Olsén, KH;Grahn, M;Langefors, Å
通讯作者：
Langefors, Å
影响因子：
64.8
作者：
SINGH, PB;BROWN, RE;ROSER, B
通讯作者：
ROSER, B
DOI：
10.1098/rspb.1997.0204
发表时间：
1997-10-22
影响因子：
4.7
作者：
Wedekind, C;Furi, S
通讯作者：
Furi, S
影响因子：
64.8
作者：
POTTS, WK;MANNING, CJ;WAKELAND, EK
通讯作者：
WAKELAND, EK