South Indian Children's Neurodevelopmental Outcomes After Group B Streptococcus Invasive Disease: A Matched-Cohort Study.
South Indian Children's Neurodevelopmental Outcomes After Group B Streptococcus Invasive Disease: A Matched-Cohort Study.
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DOI：
10.1093/cid/ciab792
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发表时间：
2022-01-20
期刊：
影响因子：
--
通讯作者：
Santhanam S
中科院分区：
文献类型：
--
作者：
John HB;Arumugam A;Priya M;Murugesan N;Rajendraprasad N;Rebekah G;Paul P;Chandna J;Lawn JE;Santhanam S
本研究是一项多国配对队列研究的一部分，该研究旨在评估暴露于侵袭性B族链球菌（iGBS）的儿童的长期神经发育障碍（NDI）风险。本文的具体目的是比较NDI跨域的iGBS幸存者与匹配的非iGBS组在我们的人口。在2020年1月至2021年4月期间，南印度一家医院的iGBS幸存者被确定并招募。将病例与年龄和性别匹配的非iGBS儿童进行比较。根据年龄，使用贝利婴幼儿发育量表-第3版（BSID-III）、韦氏学前和小学智力量表-第4版（WPPSI-IV）、韦氏儿童智力量表-第5版（WISC-V）、儿童行为检查表（CBCL）和Bruininks-Oseretsky运动能力测试第2版（BOT-2）对参与者进行评估。我们的队列包括35名GBS暴露儿童和65名匹配的非iGBS儿童，年龄在1-14岁之间。iGBS暴露组有17个（48.6%）儿童有≥1个领域的损伤，而非iGBS组有25（38%）例（未调整OR，1.51; 95% CI，0.65 -3.46），9例（26%）儿童患有“多领域损害”，而10例（20%）儿童患有“多领域损害”。（15.4%）（未校正OR，1.90; 95%CI，0.69 -5.24），1例（2.9%）中度至重度损伤儿童，而非iGBS组中有3例（4.6%）（未校正OR，0.60; 95%CI，0.06 -6.07）。在iGBS组中，与非iGBS组相比，更多的儿童患有运动障碍（未调整的OR，10.7; 95% CI，1.19-95.69; P = 0.034）。 与非iGBS组相比，iGBS儿童似乎有更高的运动障碍风险。
This study is part of a multicountry matched-cohort study designed to estimate the risk of long-term neurodevelopmental impairment (NDI) of children exposed to invasive group B Streptococcus (iGBS). The specific objective of this paper is to compare NDI across domains of iGBS survivors with a matched non iGBS group in our population. Survivors of iGBS in a South Indian hospital were identified and recruited between January 2020 and April 2021. Cases were compared with age- and gender-matched non iGBS children. Participants were assessed using Bayley Scales of Infant and Toddler Development–3rd edition (BSID-III), Wechsler Preschool and Primary Scale of Intelligence–4th edition (WPPSI-IV), Wechsler Intelligence Scale for Children–5th edition (WISC-V), Child Behavior Checklist (CBCL), and Bruininks-Oseretsky Test of Motor Proficiency, 2nd edition (BOT-2), depending on age. Our cohort comprised 35 GBS-exposed and 65 matched non iGBS children, aged 1–14 years. The iGBS-exposed group had 17 (48.6%) children with impairment in ≥1 domain compared to 25 (38%) in the non iGBS group (unadjusted OR, 1.51; 95% CI, .65–3.46), 9 (26%) children with “multi-domain impairment” compared to 10 (15.4%) in the non iGBS group (unadjusted OR, 1.90; 95% CI, .69–5.24), and 1 (2.9%) child with moderate to severe impairment compared to 3 (4.6%) in the non iGBS group (unadjusted OR, .60; 95% CI, .06–6.07). In the iGBS group, more children had motor impairments compared with the non iGBS group (unadjusted OR, 10.7; 95% CI, 1.19–95.69; P = .034). Children with iGBS seem at higher risk of developing motor impairments compared with a non iGBS group.
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影响因子：
2
作者：
Oommen, Samuel P.;Santhanam, Sridhar;Yadav, Bijesh
通讯作者：
Yadav, Bijesh
影响因子：
--
作者：
Paul, Proma;Procter, Simon R;Lawn, Joy E
通讯作者：
Lawn, Joy E
影响因子：
1.7
作者：
Ruan-Iu, Linda;Pendergast, Laura L.;Murray-Kolb, Laura E.
通讯作者：
Murray-Kolb, Laura E.
DOI：
10.1093/cid/cix656
发表时间：
2017-11-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Madrid L;Seale AC;Kohli-Lynch M;Edmond KM;Lawn JE;Heath PT;Madhi SA;Baker CJ;Bartlett L;Cutland C;Gravett MG;Ip M;Le Doare K;Rubens CE;Saha SK;Sobanjo-Ter Meulen A;Vekemans J;Schrag S;Infant GBS Disease Investigator Group
通讯作者：
Infant GBS Disease Investigator Group
影响因子：
168.9
作者：
Mwaniki, Michael K.;Atieno, Maurine;Lawn, Joy E.;Newton, Charles R. J. C.
通讯作者：
Newton, Charles R. J. C.