Sex, sex chromosomes and gene expression.

Sex, sex chromosomes and gene expression.
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性别、性染色体和基因表达

DOI:
10.1186/1741-7007-9-30
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发表时间:
2011-05-04
期刊:
影响因子:
5.4
通讯作者:
Wu CI
Wu CI
中科院分区:
生物学2区
文献类型:
--
作者:
Lu X;Wu CI

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在许多物种中,X 染色体的睾丸特异性基因比常染色体要少。这种偏差通​​常归因于精子发生过程中的 X 失活,但《BMC Biology》最近发表的一篇论文提供了反对果蝇中 X 失活的证据,并提出体细胞组织和睾丸而非卵巢特异性基因往往不位于 X 染色体上。在这里,我们讨论了这种偏见背后的可能机制,包括性对抗和剂量补偿。请参阅研究文章http://www.biomedcentral.com/1741-7007/9/29
The X chromosome has fewer testis-specific genes than autosomes in many species. This bias is commonly attributed to X inactivation in spermatogenesis but a recent paper inBMC Biologyprovides evidence against X inactivation inDrosophilaand proposes that somatic tissue- and testis- but not ovary-specific genes tend not to be located on the X chromosome. Here, we discuss possible mechanisms underlying this bias, including sexual antagonism and dosage compensation.See research article http://www.biomedcentral.com/1741-7007/9/29
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