Canonical nucleosome organization at promoters forms during genome activation.
Canonical nucleosome organization at promoters forms during genome activation.
复制标题
启动子处的典型核小体组织在基因组激活过程中形成
DOI：
10.1101/gr.157750.113
复制
发表时间：
2014-02
期刊：
影响因子：
7
通讯作者：
Liu XS
中科院分区：
文献类型：
--
作者：
Zhang Y;Vastenhouw NL;Feng J;Fu K;Wang C;Ge Y;Pauli A;van Hummelen P;Schier AF;Liu XS
The organization of nucleosomes influences transcriptional activity by controlling accessibility of DNA binding proteins to the genome. Genome-wide nucleosome binding profiles have identified a canonical nucleosome organization at gene promoters, where arrays of well-positioned nucleosomes emanate from nucleosome-depleted regions. The mechanisms of formation and the function of canonical promoter nucleosome organization remain unclear. Here we analyze the genome-wide location of nucleosomes during zebrafish embryogenesis and show that well-positioned nucleosome arrays appear on thousands of promoters during the activation of the zygotic genome. The formation of canonical promoter nucleosome organization is independent of DNA sequence preference, transcriptional elongation, and robust RNA polymerase II (Pol II) binding. Instead, canonical promoter nucleosome organization correlates with the presence of histone H3 lysine 4 trimethylation (H3K4me3) and affects future transcriptional activation. These findings reveal that genome activation is central to the organization of nucleosome arrays during early embryogenesis.
登录
查看更多内容
影响因子：
30.8
作者：
He, Housheng Hansen;Meyer, Clifford A.;Shin, Hyunjin;Bailey, Shannon T.;Wei, Gang;Wang, Qianben;Zhang, Yong;Xu, Kexin;Ni, Min;Lupien, Mathieu;Mieczkowski, Piotr;Lieb, Jason D.;Zhao, Keji;Brown, Myles;Liu, X. Shirley
通讯作者：
Liu, X. Shirley
影响因子：
16.8
作者：
Li, Zhaoyu;Schug, Jonathan;Tuteja, Geetu;White, Peter;Kaestner, Klaus H.
通讯作者：
Kaestner, Klaus H.
影响因子：
16.8
作者：
Nekrasov, Maxim;Amrichova, Jana;Tremethick, David J.
通讯作者：
Tremethick, David J.
影响因子：
64.5
作者：
Rahl PB;Lin CY;Seila AC;Flynn RA;McCuine S;Burge CB;Sharp PA;Young RA
通讯作者：
Young RA
影响因子：
2.7
作者：
Radman-Livaja, Marta;Rando, Oliver J.
通讯作者：
Rando, Oliver J.