Nucleosome positioning: how is it established, and why does it matter?

Nucleosome positioning: how is it established, and why does it matter?
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DOI:
10.1016/j.ydbio.2009.06.012
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发表时间:
2010-03-15
影响因子:
2.7
通讯作者:
Rando, Oliver J.
Rando, Oliver J.
中科院分区:
生物学3区
文献类型:
--
作者:
Radman-Livaja, Marta;Rando, Oliver J.

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将真核基因组包装到染色质中会影响 DNA 上发生的每个过程。核小体在底层 DNA 上的定位在这些过程的调节中起着关键作用,因为核小体会遮挡底层 DNA 序列。在这里,我们回顾了各种生物体中核小体位置图谱的文献,讨论了核小体位置是如何建立的,核小体定位对基因表达的控制有何影响,并探讨了染色质包装、序列进化和基因表达程序进化之间的相关性。
Packaging of eukaryotic genomes into chromatin affects every process that occurs on DNA. The positioning of nucleosomes on underlying DNA plays a key role in regulation of these processes, as the nucleosome occludes underlying DNA sequences. Here, we review the literature on mapping nucleosome positions in various organisms, and discuss how nucleosome positions are established, what effect nucleosome positioning has on control of gene expression, and touch on the correlations between chromatin packaging, sequence evolution, and the evolution of gene expression programs.
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