Detection of fusobacterium nucleatum and fadA adhesin gene in patients with orthodontic gingivitis and non-orthodontic periodontal inflammation.
Detection of fusobacterium nucleatum and fadA adhesin gene in patients with orthodontic gingivitis and non-orthodontic periodontal inflammation.
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DOI：
10.1371/journal.pone.0085280
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xiao S
中科院分区：
文献类型：
--
作者：
Liu P;Liu Y;Wang J;Guo Y;Zhang Y;Xiao S
具核梭杆菌是最常见的革兰阴性杆菌之一，与牙周病密切相关。目前还不清楚F。核仁参与正畸矫治器下的牙龈炎症。FadA是口腔梭菌所特有的一种新型粘附素，是F.具核质结合和侵入上皮细胞，因此可能在梭杆菌在宿主中的定殖中起重要作用。在这项研究中，我们评估了F。采用PCR方法检测55例正畸治疗牙龈炎患者、49例未正畸治疗牙龈炎患者、35例牙周炎患者和30例牙周健康者的169份龈下生物膜中核仁及其毒力因子FadA粘附基因（fadA）的表达。F.同时分析nucleatum/fadA和牙龈炎指数（GI）。F. nucleatum/fadA在牙周炎组和非正畸龈炎组均高于其他两组（p<0.01），正畸龈炎组高于健康人（p<0.05）。F. nucleatum/fadA和GI。F.与正畸牙龈炎相比，携带fadA的核仁可能与牙龈炎和牙周病的发展更密切相关。
Fusobacterium nucleatum is one of the most abundant gram-negative bacilli colonizing the subgingival plaque and closely associated with periodontal disease. However it is unclear whether F. nucleatum is involved in gingival inflammation under orthodontic appliance. A novel adhesin, FadA, which is unique to oral Fusobacteria, is required for F. nucleatum binding and invasion to epithelial cells and thus may play an important role in colonization of Fusobacterium in the host. In this study, we evaluated the prevalence of F. nucleatum and its virulence factor FadA adhesion gene (fadA) in 169 subgingival biofilm samples from 55 cases of gingivitis patients with orthodontic appliances, 49 cases of gingivitis patients without orthodontic treatment, 35 cases of periodontitis patients and 30 cases of periodontally healthy people via PCR. The correlations between the F. nucleatum/fadA and gingivitis index(GI)was also analyzed. The detection rate of F. nucleatum/fadA in periodontitis group and non-orthodontic gingivitis group was higher than the other two groups (p<0.01) while it was higher in orthodontic gingivitis group than in health people (p<0.05). An obviously positive correlation was observed between the prevalence of F. nucleatum/fadA and GI. F. nucleatum carrying fadA may be more closely related to the development of gingivitis and periodontal disease compared with orthodontic gingivitis.
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DOI：
10.1016/0889-5406(91)70071-4
发表时间：
1991-10-01
影响因子：
3
作者：
ALEXANDER, SA
通讯作者：
ALEXANDER, SA
影响因子：
4.3
作者：
Gursoy, Ulvi K.;Pollanen, Marja;Uitto, Veli-Jukka
通讯作者：
Uitto, Veli-Jukka
影响因子：
3.4
作者：
Kim, Sang-Ho;Choi, Dong-Soon;Song, Jae-Seok
通讯作者：
Song, Jae-Seok
影响因子：
--
作者：
Gursoy, U. K.;Koenonen, E.;Uitto, V. -J.
通讯作者：
Uitto, V. -J.
影响因子：
6.7
作者：
MOMBELLI, A;GUSBERTI, FA;LANG, NP
通讯作者：
LANG, NP