Cocaine- and morphine-induced synaptic plasticity in the nucleus accumbens.
Cocaine- and morphine-induced synaptic plasticity in the nucleus accumbens.
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DOI：
10.1002/syn.20849
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发表时间：
2011-04
期刊：
影响因子：
2.3
通讯作者：
Berlanga, Monica L.
中科院分区：
文献类型：
--
作者：
Alcantara, Adriana A.;Lim, Helen Y.;Floyd, Christopher E.;Garces, Juanita;Mendenhall, John M.;Lyons, Chelsea L.;Berlanga, Monica L.
涉及药物滥用和依赖的关键脑区和分子机制已被广泛研究。然而，药物诱导的持续行为，如致敏、耐受性或复发，远远超过任何先前报道的机制。因此，成瘾领域的一个挑战是确定药物引起的大脑回路的变化，这种变化可能会导致长期的行为变化。本研究检查了反复服用可卡因或吗啡后伏隔核（NAc）内突触连通性改变的行为变化和电子显微镜证据。采用无偏定量立体物理矢度法估计每个神经元的突触数。在可卡因和吗啡处理的大鼠NAc外壳（49.1%）和可卡因处理的大鼠NAc核心（49.1%）中发现突触与神经元的比例增加。该研究提供了药物诱导突触可塑性的直接超微结构证据，并确定突触重塑是药物诱导行为致敏的潜在神经基质。
The critical brain areas and molecular mechanisms involved in drug abuse and dependence have been extensively studied. Drug-induced persistent behaviors such as sensitization, tolerance or relapse, however, far outlast any previously reported mechanisms. A challenge in the field of addiction, therefore, has been to identify drug-induced changes in brain circuitry that may subserve long-lasting changes in behavior. The present study examined behavioral changes and electron microscopic evidence of altered synaptic connectivity within the nucleus accumbens (NAc) following repeated administration of cocaine or morphine. The unbiased quantitative stereological physical disector method was used to estimate the number of synapses per neuron. Increases in synapse to neuron ratio were found in the NAc shell of cocaine-treated (49.1%) and morphine-treated (55.1%) rats and in the NAc core of cocaine-treated animals (49.1%). This study provides direct ultrastructural evidence of drug-induced synaptic plasticity and identifies synaptic remodeling as a potential neural substrate underlying drug-induced behavioral sensitization.
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DOI：
10.1016/0091-3057(91)90112-f
发表时间：
1991-12
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Broderick PA
通讯作者：
Broderick PA
影响因子：
5.3
作者：
Cooke, BM;Woolley, CS
通讯作者：
Woolley, CS
影响因子：
2.7
作者：
Anderson, BJ;Alcantara, AA;Greenough, WT
通讯作者：
Greenough, WT
影响因子：
3.3
作者：
Cadoni, C;Di Chiara, G
通讯作者：
Di Chiara, G
影响因子：
3
作者：
BRAENDGAARD, H;GUNDERSEN, HJG
通讯作者：
GUNDERSEN, HJG