Cocaine: on-line analysis of an accumbens amine neural basis for psychomotor behavior.
Cocaine: on-line analysis of an accumbens amine neural basis for psychomotor behavior.
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DOI：
10.1016/0091-3057(91)90112-f
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发表时间：
1991-12
期刊：
影响因子：
--
通讯作者：
Broderick PA
中科院分区：
文献类型：
--
作者：
Broderick PA
用在体伏安法研究了皮下注射可卡因对行为大鼠多巴胺能和多巴胺能神经元回路中延髓核的影响。同时，在每个剂量的可卡因，可卡因诱导的无条件精神兴奋行为进行了研究，在多个并发措施的自发行为和运动的活动模式。时程研究表明，可卡因（10、20和40 mg/kg SC）的神经化学作用以剂量反应方式显著（p<0.001）增加多巴胺（DA）的突触浓度，同时显著（p<0.0001）降低5-羟色胺（5-HT）的突触浓度。同时进行的行为时程研究表明，可卡因（10、20和40 mg/kg SC）显著（p<0.0001）增加了步行（自发活动）、精细运动（嗅闻和梳理的刻板运动）和直立行为，同时显著降低了广场恐怖行为，如通过中央步行的统计学显著增加所测量的（p<0.0001）。高剂量可卡因（40 mg/kg SC）显著增加精细运动，超过较低剂量可卡因产生的精细运动（p<0.0002）。研究结果的一个重要方面是，DA和5-HT生物胺反应发生在心理刺激的行为范例中，这是一种已知的强化措施。另一种观点是可卡因对生物胺DA和5-HT的作用方向相反。最后，急性可卡因给药显示出对广场恐怖症（恐惧）的剂量反应抑制，这与可卡因对人体生物胺、DA和5-HT的相反作用高度相关（P = 0.983，p<0.01）。
Dose-response studies on subcutaneous cocaine were done to ascertain its effects in nucleus accumbens in dopaminergic and serotonergic neuronal circuitry in the behaving rat with in vivo voltammetry. Simultaneously, and at each dose of cocaine, unconditioned psychomotor stimulant behavior induced by cocaine was studied in terms of multiple concurrent measures of spontaneous behavior and by activity patterns of locomotion. Time course studies showed that the neurochemical effects of cocaine (10, 20, and 40 mg/kg SC) significantly (p<0.001) increased accumbens synaptic concentrations of dopamine (DA) and concurrently and significantly (p<0.0001) decreased accumbens synaptic concentrations of serotonin (5-HT) in a dose response manner. Simulataneous behavioral time course studies showed that cocaine (10, 20, and 40 mg/kg SC) significantly (p<0.0001) increased ambulations (locomotor activity), fine movements (stereotypic movements of sniffing and grooming) and rearing behavior, while significantly decreasing agoraphobic behavior, as measured by a statistically significant increase in central ambulations (p<0.0001). The high dose of cocaine (40 mg/kg SC) significantly increased fine movements over those produced by the lower doses of cocaine (p<0.0002). One import of the findings is that the DA and 5-HT biogenic amine response occurs in a behavioral paradigm of psychomotor stimulation, which is a known measure of reinforcement. Another is that the biogenic amines DA and 5-HT are affected by cocaine in this reinforcement paradigm with exactly opposite directionality. Finally, acute cocaine administration is shown to produce a dose response inhibition of agoraphobia (fear),w hich is highly correlated (ϱ=.983, p<0.01) with the opposing effects of cocaine on the accumbens biogenic amines, DA and 5-HT.
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DOI：
10.1016/0091-3057(91)90113-g
发表时间：
1991-12
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Broderick PA
通讯作者：
Broderick PA
影响因子：
4.7
作者：
PETTIT, HO;PAN, HT;JUSTICE, JB
通讯作者：
JUSTICE, JB
影响因子：
56.9
作者：
RITZ, MC;LAMB, RJ;KUHAR, MJ
通讯作者：
KUHAR, MJ
DOI：
10.1037/h0081662
发表时间：
1977-01-01
期刊：
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE
影响因子：
--
作者：
DEWIT, H;WISE, RA
通讯作者：
WISE, RA
影响因子：
6.1
作者：
PORRINO, LJ;RITZ, MC;GOLDBERG, SR
通讯作者：
GOLDBERG, SR