Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease.
Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease.
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首次缺血性中风患者的代谢综合征：患病率及其与冠心病的关联
DOI：
10.1038/s41598-022-17369-8
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发表时间：
2022-07-29
影响因子：
4.6
通讯作者：
Qiu, Chengxuan
中科院分区：
文献类型：
--
作者：
Liang, Yajun;Yan, Zhongrui;Hao, Yanlei;Wang, Qiqi;Zhang, Zuoji;She, Rui;Wang, Peng;Du, Yifeng;Lau, Joseph T. F.;Dekker, Joost;Bai, Bo;Qiu, Chengxuan
代谢综合征（MetS）与冠心病（CHD）在普通人群中有很好的相关性，但研究很少探讨其在脑卒中患者中的相关性。我们在首次缺血性卒中患者中检测代谢综合征的患病率及其与冠心病的相关性。这项基于医院的研究纳入了1851例首次缺血性卒中患者（平均年龄61.2岁，36.5%为女性），这些患者在中国山东的两家大学医院住院（2016年1月至2017年2月）。通过访谈、体格检查和实验室检查收集数据。MetS的定义遵循国家胆固醇教育计划（NCEP）标准、国际糖尿病联盟（IDF）标准和中国糖尿病学会（CDS）标准。CHD的定义遵循临床标准。使用二元逻辑回归模型分析数据。根据NECP标准，MetS的总患病率为33.4%，根据IDF标准为47.2%，根据CDS标准为32.5%，患病率随着年龄的增长而下降，女性高于男性（p < 0.05）。高血压、高甘油三酯和低HDL-C与CHD显著相关（多重校正比值比[OR]范围1.27-1.38，p < 0.05）。根据NECP标准、IDF标准和CDS标准定义的与MetS相关的CHD（与无MetS相比）的多重校正OR分别为1.27（95%置信区间1.03-1.57）、1.44（1.18-1.76）和1.27（1.03-1.57）。此外，MetS中有1-2个异常成分（与无）与CHD相关（多重校正OR范围1.66-1.72，p < 0.05）。MetS影响超过三分之一的首次缺血性卒中患者。MetS与卒中患者CHD的可能性增加相关。
The metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stroke. This hospital-based study included 1851 patients with first-ever ischemic stroke (mean age 61.2 years, 36.5% women) who were hospitalized into two university hospitals in Shandong, China (January 2016–February 2017). Data were collected through interviews, physical examinations, and laboratory tests. MetS was defined following the National Cholesterol Education Program (NCEP) criteria, the International Diabetes Federation (IDF) criteria, and the Chinese Diabetes Society (CDS) criteria. CHD was defined following clinical criteria. Data were analyzed using binary logistic regression models. The overall prevalence of MetS was 33.4% by NECP criteria, 47.2% by IDF criteria, and 32.5% by CDS criteria, with the prevalence being decreased with age and higher in women than in men (p < 0.05). High blood pressure, high triglycerides, and low HDL-C were significantly associated with CHD (multi-adjusted odds ratio [OR] range 1.27–1.38, p < 0.05). The multi-adjusted OR of CHD associated with MetS defined by the NECP criteria, IDF criteria, and CDS criteria (vs. no MetS) was 1.27 (95% confidence interval 1.03–1.57), 1.44 (1.18–1.76), and 1.27 (1.03–1.57), respectively. In addition, having 1–2 abnormal components (vs. none) of MetS was associated with CHD (multi-adjusted OR range 1.66–1.72, p < 0.05). MetS affects over one-third of patients with first-ever ischemic stroke. MetS is associated with an increased likelihood of CHD in stroke patients.
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DOI：
10.4137/cmc.s17068
发表时间：
2014
期刊：
Clinical Medicine Insights. Cardiology
影响因子：
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作者：
Fairweather D
通讯作者：
Fairweather D
影响因子：
3.7
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Mi D;Jia Q;Zheng H;Hoff K;Zhao X;Wang C;Liu G;Wang Y;Liu L;Wang X;Wang Y;Investigators for the Survey on Abnormal Glucose Regulation in Patients with Acute Stroke Across China ACROSS-China
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影响因子：
8.3
作者：
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Lip, Gregory Y. H.
影响因子：
5.3
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Matsunaga, Masaaki;Yatsuya, Hiroshi;Tamakoshi, Akiko
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Tamakoshi, Akiko
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Blair SN