Progressively increased M50 responses to repeated sounds in autism spectrum disorder with auditory hypersensitivity: a magnetoencephalographic study.
Progressively increased M50 responses to repeated sounds in autism spectrum disorder with auditory hypersensitivity: a magnetoencephalographic study.
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DOI：
10.1371/journal.pone.0102599
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Taniike M
中科院分区：
文献类型：
--
作者：
Matsuzaki J;Kagitani-Shimono K;Sugata H;Hirata M;Hanaie R;Nagatani F;Tachibana M;Tominaga K;Mohri I;Taniike M
本研究的目的是调查表现出听觉超敏反应的自闭症谱系障碍 (ASD) 儿童听觉皮层对重复听觉刺激的差异时程反应。听觉诱发场值是从 21 名患有自闭症谱系障碍 (ASD) 的男孩（其中 12 名患有听觉过敏，9 名不患有听觉过敏）和 15 名年龄匹配的典型发育对照中获得的。与其他两组相比，在时程研究中，仅患有听觉过敏的 ASD 组的 M50 偶极矩显着增加。患有听觉过敏的自闭症谱系障碍男孩也比其他两组表现出更长的反应持续时间。反应持续时间与听觉过敏的严重程度显着相关。我们认为听觉过敏与抑制处理减少有关，可能是由于感觉门控系统异常或抑制性中间神经元功能障碍所致。
The aim of this study was to investigate the differential time-course responses of the auditory cortex to repeated auditory stimuli in children with autism spectrum disorder (ASD) showing auditory hypersensitivity. Auditory-evoked field values were obtained from 21 boys with ASD (12 with and 9 without auditory hypersensitivity) and 15 age-matched typically developing controls. M50 dipole moments were significantly increased during the time-course study only in the ASD with auditory hypersensitivity compared with those for the other two groups. The boys having ASD with auditory hypersensitivity also showed more prolonged response duration than those in the other two groups. The response duration was significantly related to the severity of auditory hypersensitivity. We propose that auditory hypersensitivity is associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons.
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DOI：
10.1097/chi.0b013e31818b1c63
发表时间：
2009-01
影响因子：
13.3
作者：
Rapoport J;Chavez A;Greenstein D;Addington A;Gogtay N
通讯作者：
Gogtay N
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影响因子：
6.2
作者：
Iwata K;Matsuzaki H;Tachibana T;Ohno K;Yoshimura S;Takamura H;Yamada K;Matsuzaki S;Nakamura K;Tsuchiya KJ;Matsumoto K;Tsujii M;Sugiyama T;Katayama T;Mori N
通讯作者：
Mori N
影响因子：
2.5
作者：
de Boer, Marion;Spek, Annelies A.;Lobbestael, Jill
通讯作者：
Lobbestael, Jill
DOI：
10.1016/s0165-3806(03)00172-x
发表时间：
2003-09-10
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Gage, NM;Siegel, B;Roberts, TPL
通讯作者：
Roberts, TPL
影响因子：
5.3
作者：
Curtin, Paul C. P.;Medan, Violeta;Preuss, Thomas
通讯作者：
Preuss, Thomas