Effect of Acoustic Parameters and Microbubble Concentration on the Likelihood of Encapsulated Microbubble Coalescence.
Effect of Acoustic Parameters and Microbubble Concentration on the Likelihood of Encapsulated Microbubble Coalescence.
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DOI：
10.1016/j.ultrasmedbio.2021.06.020
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发表时间：
2021-10
影响因子：
2.9
通讯作者：
Dayton PA
中科院分区：
文献类型：
--
作者：
Le DQ;Papadopoulou V;Dayton PA
微泡造影剂通常用于治疗和诊断成像应用。在某些条件下，这些造影剂可以在超声应用时聚结并形成比初始群体更大的气泡。大微泡的形成可能影响治疗结果和成像质量。我们研究了与低压治疗和对比增强超声成像相关的临床相关超声参数，以确定它们对体外微泡聚结和随后微泡尺寸分布变化的影响。结果表明，在低频率，中等压力和高占空比的治疗超声能够形成大于2倍的初始气泡分布的气泡。此外，与在较高频率、低压和低占空比下的对比增强超声成像相关的声学参数显示气泡直径没有统计学显著变化，表明标准对比超声成像不会引起聚结。总的来说，这项工作表明，微泡聚结现象可以很容易地发生在治疗超声中使用的声学参数，产生的气泡比在商业造影剂中发现的气泡大得多，虽然聚结是不太可能是显着的诊断对比增强超声成像。这一观察结果保证了参数范围的进一步扩展和所产生影响的研究。
Microbubble contrast agents are commonly used for therapeutic and diagnostic imaging applications. Under certain conditions, these contrast agents can coalesce upon ultrasound application and form larger bubbles than the initial population. The formation of large microbubbles potentially influences therapeutic outcomes and imaging quality. We studied clinically relevant ultrasound parameters related to low-pressure therapy and contrast-enhanced ultrasound imaging to determine their effect on microbubble coalescence and subsequent changes in microbubble size distributions in vitro. Results indicate that therapeutic ultrasound at low-frequencies, moderate pressures, and high duty-cycles are capable of forming bubbles greater than 2 times larger than the initial bubble distribution. Furthermore, acoustic parameters related to contrast-enhanced ultrasound imaging that are at higher frequency, low-pressure, and low-duty cycle show no statistically significant changes in bubble diameter, suggesting that standard contrast ultrasound imaging does not cause coalescence. Overall, this work suggests that the microbubble coalescence phenomenon can readily occur at acoustic parameters used in therapeutic ultrasound, generating bubbles much larger than those found in commercial contrast agents, although coalescence is unlikely to be significant in diagnostic contrast-enhanced ultrasound imaging. This observation warrants further expansion of parameter ranges and investigation of resulting effects.
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影响因子：
3.5
作者：
Chomas, JE;Dayton, P;Ferrara, K
通讯作者：
Ferrara, K
DOI：
10.1109/tbme.2009.2034533
发表时间：
2010-01
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Choi JJ;Feshitan JA;Baseri B;Wang S;Tung YS;Borden MA;Konofagou EE
通讯作者：
Konofagou EE
影响因子：
2.9
作者：
Gessner, Ryan C.;Streeter, Jason E.;Kothadia, Roshni;Feingold, Steven;Dayton, Paul A.
通讯作者：
Dayton, Paul A.
影响因子：
2.9
作者：
Christensen-Jeffries K;Couture O;Dayton PA;Eldar YC;Hynynen K;Kiessling F;O'Reilly M;Pinton GF;Schmitz G;Tang MX;Tanter M;van Sloun RJG
通讯作者：
van Sloun RJG
DOI：
10.1007/s00259-010-1537-7
发表时间：
2010-08-01
影响因子：
9.1
作者：
Cosgrove, David;Lassau, Nathalie
通讯作者：
Lassau, Nathalie