Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
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DOI：
10.1016/j.schres.2012.06.028
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
Wexler, Bruce E.
中科院分区：
文献类型：
--
作者：
Liu, Jiacheng;Qiu, Maolin;Constable, R. Todd;Wexler, Bruce E.
静息脑血流量（CBF）的实验变化影响任务相关血氧水平依赖（BOLD）反应。由于精神分裂症患者已被证明有异常的静息CBF，我们试图确定是否患者和健康对照组之间的差异，静息CBF的BOLD反应的组间差异。在19名患者和20名健康对照者中获取BOLD图像，观察面部照片，并通过动脉旋转标记测量静息CBF。然后使用静息CBF来调整线性模型中任务相关BOLD信号增加的组差异。患者右侧基底节和双侧丘脑的静息CBF与健康对照组不同。在双侧前额叶区、视觉处理区和右侧梭状回，静息CBF和δ BOLD之间的关联是明显的。其他领域表现出显着的组，三角洲BOLD和静息CBF之间的三向相互作用。在BOLD反应中建模组差异时，对静息CBF进行分析，确定了任务相关δ BOLD反应中的组差异区域，这些区域在简单的组对比中不明显。分别位于右下额叶皮层、左前额叶皮层、左中额叶皮层和双侧额极。调整组间差异静息脑血流改变组间差异任务相关的BOLD反应在某些领域，这表明，评估静息脑血流在任务相关的BOLD研究可以提高敏感性和有效性。在多个区域，BOLD中静息CBF和任务相关信号增加之间的关系在患者和对照组之间不同，为可能的代谢和/或血管病理提供了新的证据。
Experimental changes in resting cerebral blood flow (CBF) affect task-related blood oxygenation level dependent (BOLD) responses. Since patients with schizophrenia have been shown to have abnormal resting CBF, we sought to determine whether differences between patients and healthy controls in resting CBF contributed to group differences in BOLD response. BOLD images were acquired in nineteen patients and twenty healthy controls looking at photographs of faces, and resting CBF was measured by arterial spinning labeling. Resting CBF was then used to adjust group differences in task-related BOLD signal increases in linear models. Patients had different resting CBF from healthy controls in right basal ganglion and bilateral thalami. Associations between resting CBF and delta BOLD were evident in bilateral prefrontal areas, visual processing areas and right fusiform gyrus. Other areas showed significant three-way interactions among group, delta BOLD and resting CBF. Incorporating resting CBF when modeling group differences in BOLD responses identified areas of group differences in task-related delta BOLD response that were not evident in simple group contrasts. These were in right inferior frontal cortex, left insula, left middle frontal cortex and bilateral frontal poles. Adjusting for inter-group differences in resting CBF altered inter-group differences in task-related BOLD response in some areas, suggesting that assessing resting CBF in task-related BOLD studies could increase sensitivity and validity. In multiple regions, the relationship between resting CBF and task-related signal increases in BOLD, differed between patients and controls, providing new evidence of possible metabolic and/or vascular pathology.
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影响因子：
6.6
作者：
Ferrarelli, Fabio;Tononi, Giulio
通讯作者：
Tononi, Giulio
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon
DOI：
10.1073/pnas.91.13.5903
发表时间：
1994-06-21
影响因子：
11.1
作者：
AKGOREN, N;FABRICIUS, M;LAURITZEN, M
通讯作者：
LAURITZEN, M
影响因子：
10.5
作者：
Horn, Helge;Federspiel, Andrea;Strik, Werner
通讯作者：
Strik, Werner
DOI：
10.1073/pnas.81.14.4586
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CRICK, F
通讯作者：
CRICK, F