Mechanisms underlying cortical activity during value-guided choice.

Mechanisms underlying cortical activity during value-guided choice.
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DOI:
10.1038/nn.3017
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发表时间:
2012-01-08
影响因子:
25
通讯作者:
Behrens, Timothy E. J.
Behrens, Timothy E. J.
中科院分区:
医学1区
文献类型:
--
作者:
Hunt, Laurence T.;Kolling, Nils;Soltani, Alireza;Woolrich, Mark W.;Rushworth, Matthew F. S.;Behrens, Timothy E. J.

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当在两个选项之间进行选择时,它们的价值相关性在整个大脑的神经活动中表现出来。这些表示是否反映了价值比较计算过程的基本活动,而不是与价值共变的其他计算,是未知的。在这里,我们研究了一个生物药理学上合理的网络模型中的活动,该模型将与价值相关的输入转换为分类选择。出现了一组反映价值比较的特征时变信号。我们测试了这些模型的预测记录从人类受试者进行价值导向决策的脑磁图数据。顶叶和前额叶信号与模型预测密切匹配。这些结果提供了一个机制的解释记录在价值导向的选择,并区分不同的皮层区域的活动与价值的计算角色的一种手段。
When choosing between two options, correlates of their value are represented in neural activity throughout the brain. Whether these representations reflect activity fundamental to the computational process of value comparison, as opposed to other computations covarying with value, is unknown. Here, we investigated activity in a biophysically plausible network model that transforms inputs relating to value into categorical choices. A set of characteristic time-varying signals emerged that reflect value comparison. We tested these model predictions in magnetoencephalography data recorded from human subjects performing value-guided decisions. Parietal and prefrontal signals matched closely with model predictions. These results provide a mechanistic explanation of neural signals recorded during value-guided choice, and a means of distinguishing computational roles of different cortical regions whose activity covaries with value.
额叶中的神经元编码多个决策变量的值。
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