Carcinogenic components of tobacco and tobacco smoke: A 2022 update.
Carcinogenic components of tobacco and tobacco smoke: A 2022 update.
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DOI：
10.1016/j.fct.2022.113179
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发表时间：
2022-07
影响因子：
4.3
通讯作者：
Hecht, Stephen S.
中科院分区：
文献类型：
--
作者：
Li, Yupeng;Hecht, Stephen S.
烟草和烟草烟雾含有超过9500种化学化合物的复杂混合物，其中许多已被监管机构认定为对人类健康有害。2012年，美国食品和药物管理局制定了未燃烧烟草和烟草烟雾中有害和潜在有害成分的清单，其中79种被认为是致癌物质。在过去的10年里，随着分析技术的进步，大量新的数据已经公布，增加了我们对烟草制品中致癌物水平的了解。国际癌症研究机构（IARC）自2012年以来发布了35本专著，其中未燃烧的烟草和烟草烟雾中越来越多的化合物被列为致癌物。在本文中，我们提供了未燃烧的烟草和烟草主流烟雾中的IARC分类致癌物的最新列表。自2012年以来，共有83种致癌物被确定-未燃烧的烟草中有37种，烟草烟雾中有80种-其发生水平已被报告。近年来，没有观察到任何这些致癌物的明显下降趋势。需要监测烟草致癌物的含量并采取管制行动，以确保控制其含量，从而降低患癌症和其他疾病的潜在风险。
Tobacco and tobacco smoke contain a complex mixture of over 9500 chemical compounds, many of which have been recognized as hazardous to human health by regulatory agencies. In 2012, the U.S. Food and Drug Administration established a list of harmful and potentially harmful constituents in unburned tobacco and tobacco smoke, 79 of which are considered as carcinogens. Over the past 10 years, with advancing analytical technology, significant amounts of new data have been published, increasing our understanding of levels of carcinogens in tobacco products. The International Agency for Research on Cancer (IARC) has released 35 monographs since 2012, with an increasing number of compounds in unburned tobacco and tobacco smoke classified as carcinogens. In this paper, we provide an updated list of IARC-classified carcinogens in unburned tobacco and tobacco mainstream smoke. A total of 83 carcinogens has been identified – 37 in unburned tobacco and 80 in tobacco smoke – with their occurrence levels reported since 2012. No clear decreasing trends were observed for any of these carcinogens in recent years. Surveillance of the levels of tobacco carcinogens as well as regulatory actions are needed to ensure control of their levels so that potential reduced risks of cancer and other diseases may be achieved.
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