Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood.
Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood.
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DOI：
10.1002/mnfr.201700722
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发表时间：
2018-04
影响因子：
5.2
通讯作者：
Pasinetti GM
中科院分区：
文献类型：
--
作者：
Blaze J;Wang J;Ho L;Mendelev N;Haghighi F;Pasinetti GM
压力是人类和动物各种疾病的已知诱因，但其机制仍不清楚。在动物中，社会心理压力引起的抑郁/焦虑表型与大脑和血液炎症的增加同时发生。作者最近表明，采用精选生物活性多酚制剂进行的新型治疗可提高小鼠对压力介导的抑郁/焦虑表型的恢复能力。此外，多酚制剂中的选择性生物活性酚类化合物可有效减轻应激小鼠骨髓移植的行为影响。在这里，成人应激和骨髓移植的动物模型被用来识别重复社会失败应激（RSDS）的表观遗传特征，该特征通过骨髓造血祖细胞传递给幼鼠，揭示了应激后中枢和外周表观遗传记忆的维持。此外，将多酚给予幼稚小鼠和应激敏感小鼠，表明对来自易感小鼠和幼稚供体的小鼠进行多酚治疗会改变中枢神经系统和外周的整体DNA甲基化，同样对免疫攻击后的人类血细胞产生影响。研究结果强调了压力的持久分子记忆，以及精选生物活性多酚可能促进压力恢复的可能机制。多酚可能是精神病学中传统药物治疗的有效替代品。
Stress is a known contributor to various forms of disease in humans and animals, although mechanisms are still unknown. In animals, psychosocial stress-induced depression/anxiety phenotypes are coincidental with increased inflammation in both brain and blood. The authors recently showed that a novel treatment with a select bioactive polyphenol preparation promotes resilience to stress-mediated depression/anxiety phenotypes mice. Moreover, selective bioactive phenolic compounds within the polyphenol preparation are identified that are effective in mitigating the behavioral effects of bone marrow transplantation from stressed mice. Here, an animal model of adult stress and bone marrow transplantation is used to identify an epigenetic signature of repeated social defeat stress (RSDS) that is passed through bone marrow hematopoietic progenitor cells to naïve mice, revealing the maintenance of epigenetic memory following stress both centrally and peripherally. Further, polyphenols are administered to naïve and stress-susceptible mice, demonstrating that polyphenol treatment in mice from both susceptible and naïve donors alters global DNA methylation in the central nervous system and periphery and likewise has an effect on human blood cells after immune challenge. Findings highlight the enduring molecular memory of stress and the possible mechanism by which select bioactive polyphenols may promote resiliency to stress. Polyphenols may be an efficacious alternative to traditional pharmacological treatments in psychiatry.
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影响因子：
7.3
作者：
Blaze J;Roth TL
通讯作者：
Roth TL
影响因子：
11.1
作者：
Stenvinkel, P.;Karimi, M.;Schalling, M.
通讯作者：
Schalling, M.
影响因子：
16.6
作者：
Wang J;Hodes GE;Zhang H;Zhang S;Zhao W;Golden SA;Bi W;Menard C;Kana V;Leboeuf M;Xie M;Bregman D;Pfau ML;Flanigan ME;Esteban-Fernández A;Yemul S;Sharma A;Ho L;Dixon R;Merad M;Han MH;Russo SJ;Pasinetti GM
通讯作者：
Pasinetti GM
鉴定小鼠和男性的抗性和循环皮肤树突状细胞种群。
影响因子：
15.3
作者：
Bogunovic, Milena;Ginhoux, Florent;Wagers, Amy;Loubeau, Martine;Isola, Luis M.;Lubrano, Lauren;Najfeld, Vesna;Phelps, Robert G.;Grosskreutz, Celia;Scigliano, Eilleen;Frenette, Paul S.;Merad, Miriam
通讯作者：
Merad, Miriam
影响因子：
56.9
作者：
Brazelton, TR;Rossi, FMV;Blau, HM
通讯作者：
Blau, HM