Conserved function of mediator in regulating nuclear hormone receptor activation between plants and animals.

Conserved function of mediator in regulating nuclear hormone receptor activation between plants and animals.
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调节植物和动物核激素受体激活的介质的保守功能

DOI:
10.1080/15592324.2017.1403709
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发表时间:
2018
影响因子:
2.9
通讯作者:
Li C
Li C
中科院分区:
生物学4区
文献类型:
--
作者:
Zhai Q;Li L;An C;Li C

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摘要对植物激素茉莉酸异亮氨酸(JA-Ile)的感知涉及SCF型E3泛素连接酶的F-box亚单位COI1与其底物茉莉酸ZIM结构域(JAZ)转录抑制物之间形成共受体复合体的过程。在最近的研究中,我们发现拟南芥介体的一个亚基MED25在物理和功能上与COI1和主转录因子MYC2在MYC2靶启动子上相互作用。在这里,我们提供了MED25也与Jaz蛋白的子集物理上相互作用的证据。因此,JA-Ile共受体复合体SCFCOI1-JAZs和主要转录因子MYC2在与介体相互作用方面类似于后生动物的核激素受体系统。此外,我们还发现,植物MED25和动物MED25在不同的信号通路中也与类似的表观遗传调控因子合作。我们的研究揭示了这样一种情景,即植物和动物在转录调控水平上进化出了不同的、但基本上相似的核激素受体激活机制。
ABSTRACT Perception of the plant hormone jasmonoyl-isoleucine (JA-Ile) involves the formation of a co-receptor complex between COI1, the F-box subunit of a SCF-type E3 ubiquitin ligase, and its substrates, a group of jasmonate ZIM-domain (JAZ) transcriptional repressors. In recent studies, we show that MED25, a subunit of the Arabidopsis Mediator, physically and functionally interacts with COI1 and the master transcription factor MYC2 on MYC2 target promoters. Here we provide evidence that MED25 also physically interacts with a subset of JAZ proteins. Therefore, in term of their interaction with Mediator, the JA-Ile co-receptor complex SCFCOI1-JAZs together with the master transcription factor MYC2 resembles the nuclear hormone receptor system of metazoans. In addition, we show that the plant MED25 and its animal counterpart also cooperates with similar epigenetic regulators in distinct signaling pathways. Our study reveals a scenario that plants and animals have evolved distinct, yet largely similar, mechanism for nuclear hormone receptor activation at the level of transcriptional regulation.
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影响因子: --
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