Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration.
Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration.
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DOI：
10.1007/s00213-010-1913-9
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发表时间：
2010-09
影响因子：
3.4
通讯作者：
West, Mark O.
中科院分区：
文献类型：
--
作者：
Barker, David J.;Root, David H.;Ma, Sisi;Jha, Shaili;Megehee, Laura;Pawlak, Anthony P.;West, Mark O.
自我服用可卡因和其他滥用药物的动机动机尚未完全了解。一个新出现的因素是情感。积极和消极的情感状态都被假设影响药物寻求和药物服用。与此同时，褐家鼠的超声波发声（USVs）也被认为可以帮助我们了解动物的情感反应。此外，研究表明，中边缘多巴胺（DA）在可卡因自我给药和USV产生中起着关键作用。因此，啮齿动物usv测量的情感加工可能与可卡因自我给药相吻合，但迄今尚未研究。本研究检测了大鼠自我给药低剂量（0.355 mg/kg/输注）和高剂量（0.71 mg/kg/输注）可卡因时消极情感（18-32.99 kHz）和积极情感（38-80 kHz）范围内的usv。两个剂量组均观察到两个范围内的usv。低剂量动物的叫声主要发生在22 kHz范围内（18-32.99 kHz），但比传统的22 kHz叫声持续时间短（10-500 ms）。相比之下，高剂量组的usv主要在50-kHz频率范围内观察到（38-80 kHz），通常与食欲结果相关。这些结果为可卡因自我给药过程中usv的存在提供了证据。观察到的usv剂量依赖性差异为情感是影响人类药物使用和复发行为的潜在动机因素这一观点提供了新的支持。啮齿动物usv可能为理解情感在成瘾中的作用提供了有力的工具。
The motivational impetuses underlying self-administration of cocaine and other drugs of abuse are not fully understood. One emerging factor is affect. Both positive and negative affective states have been hypothesized to influence drug seeking and drug taking. In parallel, it has been posited that the ultrasonic vocalizations (USVs) of Rattus norvegicus provide insight into the animals’ affective reactions. Furthermore, it has been shown that mesolimbic dopamine (DA) plays a key role in cocaine self-administration and in USV production. Thus, affective processing as measured by rodent USVs likely coincides with cocaine self-administration, but to date has not been studied. The present study examined USVs in both the negative affective (18–32.99 kHz) and positive affective (38–80 kHz) ranges of rats during self-administration of a low (0.355 mg/kg/infusion) or high (0.71 mg/kg/infusion) dose of cocaine. USVs in both ranges were observed in both dose groups. Vocalizations of the low-dose animals occurred primarily in the 22-kHz range (18–32.99 kHz), but exhibited shorter durations (10–500 ms) than those traditionally observed for 22-kHz calls in aversive situations. In contrast, USVs of the high-dose group were primarily observed in the 50-kHz frequency range (38–80 kHz), typically associated with appetitive outcomes. These results provide evidence for the presence of USVs during cocaine self-administration. The observed dose-dependent difference in USVs provides novel support for the view that affect is one potential motivational factor influencing human drug use and relapse behaviors. Rodent USVs may provide a powerful tool for understanding the role of affect in addiction.
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影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
DOI：
10.1111/j.1749-6632.1986.tb27996.x
发表时间：
1986-12-31
影响因子：
5.2
作者：
BARFIELD, RJ;THOMAS, DA
通讯作者：
THOMAS, DA
影响因子：
1.9
作者：
Burgdorf, J;Knutson, B;Ikemoto, S
通讯作者：
Ikemoto, S
影响因子：
3.6
作者：
FU, XW;BRUDZYNSKI, SM
通讯作者：
BRUDZYNSKI, SM
影响因子：
2.5
作者：
Brudzynski, Stefan M.
通讯作者：
Brudzynski, Stefan M.