Serum retinol binding protein 4 is associated with visceral fat in human with nonalcoholic fatty liver disease without known diabetes: a cross-sectional study.
Serum retinol binding protein 4 is associated with visceral fat in human with nonalcoholic fatty liver disease without known diabetes: a cross-sectional study.
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血清视黄醇结合蛋白 4 与患有非酒精性脂肪肝且无已知糖尿病的人的内脏脂肪相关：一项横断面研究
DOI：
10.1186/s12944-015-0033-2
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发表时间：
2015-04-16
影响因子：
4.5
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Chang X;Yan H;Bian H;Xia M;Zhang L;Gao J;Gao X
背景高血清视黄醇结合蛋白4（RBP 4）水平与人类胰岛素抵抗状态有关。为明确人体内哪些脂肪区与RBP 4水平升高相关，我们检测了106例非酒精性脂肪性肝病（NAFLD）患者的血清RBP 4水平、肝脏脂肪含量（HFC）、内脏脂肪（VFA）和皮下腹部脂肪面积（SFA）。排除已知患有糖尿病、慢性病毒性肝炎、饮酒量男性≥30 g/d、女性≥20 g/d的受试者。进行人体测量学和实验室检查，包括血脂、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和γ-谷氨酰转移酶（γ-GT）。通过CT扫描测定HFC、VFA和SFA。结果循环RBP 4与高密度脂蛋白胆固醇（HDL-c）呈负相关。（r =-0.392，p < 0.001），但与腰臀比（WHR）呈正相关（r = 0.343，p = 0.001），甘油三酯（r = 0.330，p = 0.002），VFA（r = 0.298，p = 0.027），收缩压（r = 0.247，p = 0.020）、舒张压（r = 0.241，p = 0.023）、γ-GT（r = 0.239，p = 0.034）、腰围（r = 0.218，p = 0.040）。但血清RBP 4水平与HFC（r = 0.199，p = 0.071）、SFA、年龄、BMI、总胆固醇、低密度脂蛋白胆固醇（LDL-c）、ALT或AST（均p> 0.05）无关。多元线性回归分析显示，RBP 4与所有受试者中的VFA（标准β = 0.357，p = 0.019）和HDL-c（标准β =-0.345，p = 0.023）独立相关，男性中的HDL-c（标准β =-0.315，p = 0.040），女性中的VFA/SFA（标准β = 0.471，p = 0.049）独立相关，而与HFC无关。当HFC低于6.34%时，血清RBP 4与HFC呈正相关（r = 0.574，p = 0.001）。结论RBP 4可作为腹型肥胖的一个标志物，但其在NAFLD发病中的作用尚不清楚。
BackgroundHigh serum Retinol Binding Protein 4 (RBP4) levels were associated with insulin-resistant states in humans. To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured serum RBP4 and hepatic fat content (HFC), visceral (VFA) and subcutaneous abdominal fat area (SFA) in 106 subjects with non-alcoholic fatty liver disease (NAFLD) without known diabetes.Methods106 patients with NAFLD (M/F: 61/45, aged 47.44 ± 14.16 years) were enrolled. Subjects with known diabetes, chronic virus hepatitis, and those with alcohol consumption ≥30 g/d in man and ≥20 g/d in woman were excluded. Anthropometrics and laboratory tests, including lipid profile, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltransferase (γ-GT) were conducted. HFC, VFA and SFA were determined by CT scan. Serum RBP4 was detected by an enzyme immunoassay kit and validated by quantitative Western blotting.ResultsCirculating RBP4 was negatively associated with high-density lipoprotein cholesterol (HDL-c) (r = −0.392,p< 0.001), but positively with waist-to-hip ratio (WHR) (r = 0.343,p= 0.001), triglyceride (r = 0.330,p= 0.002), VFA (r = 0.298,p= 0.027), systolic blood pressure (r = 0.247,p= 0.020), diastolic blood pressure (r = 0.241,p= 0.023), γ-GT (r = 0.239,p= 0.034), waist circumference (r = 0.218,p= 0.040). Differently, serum RBP4 levels were not associated with HFC (r = 0.199, p = 0.071), SFA, age, BMI, total cholesterol, low-density lipoprotein cholesterol (LDL-c), ALT or AST (allp> 0.05). Multiple linear regression analysis revealed that RBP4 correlated independently with VFA (Standard β = 0.357,p= 0.019) and HDL-c (Standard β = −0.345,p= 0.023) in all subjects, HDL-c (Standard β = −0.315,p= 0.040) in men, VFA/SFA in women (Standard β = 0.471,p= 0.049), not with HFC. However, serum RBP4 was positively correlated with HFC when HFC below 6.34% (r = 0.574,p= 0.001).ConclusionsRBP4 could be a marker of abdominal obesity, however, the role of RBP4 in the pathogenesis of NAFLD is not sufficiently elucidated.
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影响因子：
3.2
作者：
Mansouri M;Nikooie R;Keshtkar A;Larijani B;Omidfar K
通讯作者：
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3.7
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Kotnik P;Keuper M;Wabitsch M;Fischer-Posovszky P
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13.5
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通讯作者：
George, Jacob
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29
作者：
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通讯作者：
Kahn, Barbara B.
影响因子：
158.5
作者：
Graham, Timothy E.;Yang, Qin;Kahn, Barbara B.
通讯作者：
Kahn, Barbara B.