Multilayer control of cardiac electrophysiology by microRNAs.
Multilayer control of cardiac electrophysiology by microRNAs.
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DOI：
10.1016/j.yjmcc.2022.02.007
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发表时间：
2022-05
影响因子：
5
通讯作者：
Fu, Ji-Dong
中科院分区：
文献类型：
--
作者：
Yang, Dandan;Desche, Isabelle;Fu, Ji-Dong
心脏的电生理特性包括心脏的自律性，单个心肌细胞的兴奋(即动作电位的去极化和复极化)，以及在整个心脏中高度协调的电传播。这些特性中的任何一个的异常都可能导致心律失常。通过传统的RNA干扰(RNAi)机制，microRNAs(MiRs)被认为是基因表达的重要调节因子，并参与了多种生物学事件。最近的证据表明，miRs通过传统的RNAi机制对离子通道、转运体、细胞内钙处理蛋白等相关因素的表达进行精细调控，从而调节心脏的电生理。最近，心脏中MIR与离子通道之间的直接相互作用也被报道，揭示了MIR对心脏电生理的生物物理调节作用。这些先进的发现表明，miR通过两种不同的机制控制心脏电生理：通过生物物理调节的即时作用和长期的常规RNAi调节。在这里，我们回顾了最近的研究进展，并总结了目前对miR如何操纵离子通道功能以维持心脏电生理的动态平衡的理解。
The electrophysiological properties of the heart include cardiac automaticity, excitation (i.e., depolarization and repolarization of action potential) of individual cardiomyocytes, and highly coordinated electrical propagation through the whole heart. An abnormality in any of these properties can cause arrhythmias. MicroRNAs (miRs) have been recognized as essential regulators of gene expression through the conventional RNA interference (RNAi) mechanism and are involved in a variety of biological events. Recent evidence has demonstrated that miRs regulate the electrophysiology of the heart through fine regulation by the conventional RNAi mechanism of the expression of ion channels, transporters, intracellular Ca2+-handling proteins, and other relevant factors. Recently, a direct interaction between miRs and ion channels has also been reported in the heart, revealing a biophysical modulation by miRs of cardiac electrophysiology. These advanced discoveries suggest that miR controls cardiac electrophysiology through two distinct mechanisms: immediate action through biophysical modulation and long-term conventional RNAi regulation. Here, we review the recent research progress and summarize the current understanding of how miR manipulates the function of ion channels to maintain the homeostasis of cardiac electrophysiology.
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影响因子：
--
作者：
Antzelevitch C;Burashnikov A
通讯作者：
Burashnikov A
影响因子：
5.8
作者：
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通讯作者：
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DOI：
10.1073/pnas.1209414109
发表时间：
2012-07-31
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
20.1
作者：
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