MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery.

MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery.
复制标题

MALDI成像质谱法:空间分子分析以实现新的发现时代。

DOI:
10.1016/j.jprot.2014.03.021
复制
发表时间:
2014-07-31
影响因子:
3.3
通讯作者:
Caprioli RM
Caprioli RM
中科院分区:
生物学2区
文献类型:
--
作者:
Gessel MM;Norris JL;Caprioli RM

文献摘要

参考文献

被引文献

相似文献

基质辅助激光解吸/电离成像质谱 (MALDI IMS) 将质谱的灵敏度和选择性与空间分析相结合,为组织学分析提供了新的维度,从而提供组织中生物分子排列的公正可视化。因此,MALDI IMS 有能力成为生物和临床科学领域强大的新型分子技术。在这篇综述中,我们简要描述了 MALDI IMS 的几种应用,涵盖从药物到蛋白质的一系列分子量。讨论了当前的限制和挑战以及解决这些问题的最新进展。
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial analysis to provide a new dimension for histological analyses to provide unbiased visualization of the arrangement of biomolecules in tissue. As such, MALDI IMS has the capability to become a powerful new molecular technology for the biological and clinical sciences. In this review, we briefly describe several applications of MALDI IMS covering a range of molecular weights, from drugs to proteins. Current limitations and challenges are discussed along with recent developments to address these issues.
DOI: 10.1016/j.jasms.2009.01.017
发表时间: 2009-06
影响因子: 3.2
作者:
Chen R;Hui L;Sturm RM;Li L
通讯作者: Li L
DOI: 10.1016/j.chom.2012.04.018
发表时间: 2012-06-14
影响因子: 30.3
作者:
Attia, Ahmed S.;Schroeder, Kaitlin A.;Skaar, Eric P.
通讯作者: Skaar, Eric P.
DOI: 10.1074/mcp.m113.034769
发表时间: 2014-01
期刊: Molecular & cellular proteomics : MCP
影响因子: --
作者:
Hebert AS;Richards AL;Bailey DJ;Ulbrich A;Coughlin EE;Westphall MS;Coon JJ
通讯作者: Coon JJ
DOI: 10.1007/s13361-010-0013-8
发表时间: 2011-01
影响因子: 3.2
作者:
Grove, Kerri J.;Frappier, Sara L.;Caprioli, Richard M.
通讯作者: Caprioli, Richard M.
DOI: 10.1038/nmeth1145
发表时间: 2008-01-01
期刊: NATURE METHODS
影响因子: 48
作者:
Andersson, Malin;Groseclose, M. Reid;Caprioli, Richard M.
通讯作者: Caprioli, Richard M.