Anterior medial prefrontal cortex exhibits activation during task preparation but deactivation during task execution.
Anterior medial prefrontal cortex exhibits activation during task preparation but deactivation during task execution.
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DOI：
10.1371/journal.pone.0022909
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Osaka N
中科院分区：
文献类型：
--
作者：
Koshino H;Minamoto T;Ikeda T;Osaka M;Otsuka Y;Osaka N
前额叶皮质(PFC)在一些认知任务中表现出激活作用，包括情景记忆、推理、注意、多任务、任务集、决策、心理化和自我参照信息的处理。然而，前PFC的内侧部分是默认模式网络(DMN)的一部分，与静止基线相比，该网络在各种目标定向认知任务中显示出去激活。这种模式的一个可能因素是，前内侧PFC(MPFC)的活动受到注意资源根据任务需求的动态分配的影响。我们使用与事件相关的fMRI和面孔工作记忆任务来研究这种可能性。16名学生参加了一次功能磁共振成像会议。他们被要求组成一个任务集来记忆面孔(面孔记忆条件)或忽略它们(无面孔记忆条件)，然后在面孔刺激开始之前给予他们6秒的准备时间。在这段6秒的时间里，四个个位数一次一个地出现在显示屏的中央，参与者被要求添加这些数字并记住最终答案。当参与者形成一个记住面孔的任务集时，在一次实验中，前MPFC在任务准备阶段表现出激活，而在任务执行阶段表现出去激活。结果表明，前MPFC参与了任务集的形成，但不参与面孔工作记忆任务的执行。因此，当注意资源在任务执行过程中被分配到其他脑区时，前部MPFC显示失活。结果表明，前MPFC的激活和去激活受到加工资源在加工不同阶段的动态分配的影响。
The anterior prefrontal cortex (PFC) exhibits activation during some cognitive tasks, including episodic memory, reasoning, attention, multitasking, task sets, decision making, mentalizing, and processing of self-referenced information. However, the medial part of anterior PFC is part of the default mode network (DMN), which shows deactivation during various goal-directed cognitive tasks compared to a resting baseline. One possible factor for this pattern is that activity in the anterior medial PFC (MPFC) is affected by dynamic allocation of attentional resources depending on task demands. We investigated this possibility using an event related fMRI with a face working memory task. Sixteen students participated in a single fMRI session. They were asked to form a task set to remember the faces (Face memory condition) or to ignore them (No face memory condition), then they were given 6 seconds of preparation period before the onset of the face stimuli. During this 6-second period, four single digits were presented one at a time at the center of the display, and participants were asked to add them and to remember the final answer. When participants formed a task set to remember faces, the anterior MPFC exhibited activation during a task preparation period but deactivation during a task execution period within a single trial. The results suggest that the anterior MPFC plays a role in task set formation but is not involved in execution of the face working memory task. Therefore, when attentional resources are allocated to other brain regions during task execution, the anterior MPFC shows deactivation. The results suggest that activation and deactivation in the anterior MPFC are affected by dynamic allocation of processing resources across different phases of processing.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
1.9
作者：
Christoff, K;Ream, JM;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
2.6
作者：
de Zubicaray, GI;Zelaya, FO;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
3.2
作者：
Gazzaley, A;Cooney, JW;D'Esposito, M
通讯作者：
D'Esposito, M