Depressive symptoms enhance stress-induced inflammatory responses.
Depressive symptoms enhance stress-induced inflammatory responses.
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DOI：
10.1016/j.bbi.2012.05.006
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发表时间：
2013-07
影响因子：
15.1
通讯作者：
Kiecolt-Glaser, Janice K.
中科院分区：
文献类型：
--
作者：
Fagundes, Christopher P.;Glaser, Ronald;Hwang, Beom Seuk;Malarkey, William B.;Kiecolt-Glaser, Janice K.
抑郁症是发病率和死亡率的一个危险因素，免疫失调可能是造成这种联系的部分原因。促炎细胞因子如白细胞介素6（IL-6）是生活质量、发病率和许多死亡原因的可靠预测因子。目前的研究评估了抑郁症状（由CES-D评估）与应激诱导的炎症之间的关系。参与者，138名健康成年人，在休息时进行了评估，并在标准化的实验室语音和心算压力。与抑郁症状较少的个体相比，抑郁症状较多的个体在应对压力源时产生更多的IL-6，并且在压力源后45分钟和2小时产生显着更高的IL-6水平。这些发现增加了我们对压力，抑郁和免疫失调之间复杂相互作用的理解，并提供了一种解释抑郁症状和疾病之间关系的潜在途径。
Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. The participants, 138 healthy adults, were evaluated at rest, and after a standardized laboratory speech and mental arithmetic stressor. Compared with individuals with fewer depressive symptoms, those with more depressive symptoms produced more IL-6 in response to the stressor, as well as significantly higher levels of IL-6 both 45 minutes and 2 hours after the stressor. These findings add to our emerging understanding of the complex interactions among stress, depression, and immune dysregulation, and provide one potential pathway to explain relationships between depressive symptoms and disease.
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DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
10.6
作者：
Miller, Andrew H.;Maletic, Vladimir;Raison, Charles L.
通讯作者：
Raison, Charles L.
影响因子：
--
作者：
Pan, An;Lucas, Michel;Sun, Qi;van Dam, Rob M.;Franco, Oscar H.;Willett, Walter C.;Manson, JoAnn E.;Rexrode, Kathryn M.;Ascherio, Alberto;Hu, Frank B.
通讯作者：
Hu, Frank B.
影响因子：
3.8
作者：
Maes, M;Song, C;Smith, RS
通讯作者：
Smith, RS
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH