Circular RNAs in Cancer - Lessons Learned From microRNAs.
Circular RNAs in Cancer - Lessons Learned From microRNAs.
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DOI：
10.3389/fonc.2018.00179
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发表时间：
2018
影响因子：
4.7
通讯作者：
Calin GA
中科院分区：
文献类型：
--
作者：
Dragomir M;Calin GA
环状RNA（circRNA）是由线性前信使RNA片段和其他线性RNA物质通过称为“反向剪接”的过程构建的RNA分子，其中3 '和5'末端连接在一起，产生共价不间断的环。circRNA并不是RNA世界的新成员;它们在20世纪90年代初首次被发现。新颖之处在于它们在哺乳动物细胞中的丰度，因为最近发现并注释了数千种circRNA。circRNA的生物发生是一个部分表征的过程，由三种不同的机制调节：外显子跳跃，内含子配对和RNA结合蛋白。另一方面，circRNA的功能在很大程度上仍然未知，只有少数奇异的报告详细描述了一些环状转录本的生物学作用。在很短的时间内，许多circRNA与各种癌症类型相关，并且在体液中也被鉴定出具有成为疾病特异性生物标志物的潜力。在这篇综述中，我们简要描述了circRNA的生物起源和功能，并介绍了文献中不止一次报道的与癌症相关的环状转录物。最后，我们指出了在癌症中研究circRNA时遇到的一些困难，因为我们认为考虑到这些困难可以加速和提高我们对circRNA在人类疾病中的生物学和翻译用途的理解。
Circular RNAs (circRNA) are RNA molecules built from fragments of linear pre-messenger RNAs and other linear RNA species through a process termed “back-splicing” in which the 3′ and 5′ ends are joined together giving rise to a covalently uninterrupted loop. circRNAs are not new members of the RNA world; they were first discovered in the early 1990s. The novelty is their abundance in the mammalian cells, as recently thousands of circRNAs were discovered and annotated. The biogenesis of circRNAs is a partially characterized process, regulated by three different mechanisms: exon skipping, intron pairing, and RNA-binding proteins. On the other hand, the function of circRNAs remains largely unknown and only a handful of singular reports describe in detail the biological roles of some circular transcripts. In a very short period of time, numerous circRNAs were associated with various cancer types and were also identified in bodily fluids with the potential of being disease-specific biomarkers. In this review, we briefly describe the biogenesis and function of circRNAs and present the circular transcripts that were more than once reported in literature to be associated with cancer. Finally, we point out some of the difficulties encountered in the study of circRNAs in cancer, as we consider that taking these into account could accelerate and improve our understanding of the biologic and translational use of circRNAs in human diseases.
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圆形RNA电路的多态性和表达模式有助于肝细胞癌的癌变。
影响因子：
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作者：
Guo W;Zhang J;Zhang D;Cao S;Li G;Zhang S;Wang Z;Wen P;Yang H;Shi X;Pan J;Ye H
通讯作者：
Ye H
影响因子：
2.9
作者：
Bolha L;Ravnik-Glavač M;Glavač D
通讯作者：
Glavač D
DOI：
10.1016/j.bbrc.2018.02.036
发表时间：
2018-02-26
影响因子：
3.1
作者：
Ji, Wenxin;Qiu, Chunli;Dai, Yinhai
通讯作者：
Dai, Yinhai
影响因子：
11.4
作者：
Hansen, Thomas B.;Wiklund, Erik D.;Kjems, Jorgen
通讯作者：
Kjems, Jorgen
影响因子：
--
作者：
Barbagallo D;Condorelli A;Ragusa M;Salito L;Sammito M;Banelli B;Caltabiano R;Barbagallo G;Zappalà A;Battaglia R;Cirnigliaro M;Lanzafame S;Vasquez E;Parenti R;Cicirata F;Di Pietro C;Romani M;Purrello M
通讯作者：
Purrello M