Ancient European dog genomes reveal continuity since the Early Neolithic.
Ancient European dog genomes reveal continuity since the Early Neolithic.
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DOI：
10.1038/ncomms16082
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发表时间：
2017-07-18
影响因子：
16.6
通讯作者：
Veeramah KR
中科院分区：
文献类型：
--
作者：
Botigué LR;Song S;Scheu A;Gopalan S;Pendleton AL;Oetjens M;Taravella AM;Seregély T;Zeeb-Lanz A;Arbogast RM;Bobo D;Daly K;Unterländer M;Burger J;Kidd JM;Veeramah KR
欧洲在狗的进化中扮演了重要角色，拥有最古老的无争议的旧石器时代遗迹，并成为现代狗品种创造的中心。在这里，我们对来自德国的新石器时代早期和晚期狗的基因组进行了测序，其中包括与早期欧洲农业社区相关的样本。这两种狗都表现出彼此的连续性，并且主要与现代欧洲狗共享祖先，这与先前提出的新石器时代晚期人口更替相矛盾。我们没有发现遗传学证据来支持最近提出的狗驯化的双重起源的假设。通过使用我们最古老的狗校准突变率，我们将狗驯化的时间缩小到20，000 - 40，000年前。有趣的是，我们没有观察到现代狗AMY 2B基因特征的极端拷贝数扩张，这种扩张以前被认为是对新石器时代农业广泛采用所驱动的富含淀粉饮食的适应。欧洲大陆被认为在现代狗的起源中发挥了重要作用。在这里，分析了来自德国的两个古老的狗的基因组，作者发现了在整个新石器时代和狗驯化到20000 - 40000年前的时间的重要遗传连续性。
Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic remains and having been the centre of modern dog breed creation. Here we sequence the genomes of an Early and End Neolithic dog from Germany, including a sample associated with an early European farming community. Both dogs demonstrate continuity with each other and predominantly share ancestry with modern European dogs, contradicting a previously suggested Late Neolithic population replacement. We find no genetic evidence to support the recent hypothesis proposing dual origins of dog domestication. By calibrating the mutation rate using our oldest dog, we narrow the timing of dog domestication to 20,000–40,000 years ago. Interestingly, we do not observe the extreme copy number expansion of the AMY2B gene characteristic of modern dogs that has previously been proposed as an adaptation to a starch-rich diet driven by the widespread adoption of agriculture in the Neolithic. The European continent is thought to have played a major role in the origins of modern dogs. Here, analysing two ancient dog genomes from Germany, the authors find significant genetic continuity throughout the Neolithic period and time dog domestication to ∼20,000–40,000 years ago.
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影响因子：
56.9
作者：
Frantz, Laurent A. F.;Mullin, Victoria E.;Larson, Greger
通讯作者：
Larson, Greger
影响因子：
3.8
作者：
Arendt, M.;Cairns, K. M.;Ballard, J. W. O.;Savolainen, P.;Axelsson, E.
通讯作者：
Axelsson, E.
DOI：
10.1126/science.1165448
发表时间：
2009-03-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anderson TM;vonHoldt BM;Candille SI;Musiani M;Greco C;Stahler DR;Smith DW;Padhukasahasram B;Randi E;Leonard JA;Bustamante CD;Ostrander EA;Tang H;Wayne RK;Barsh GS
通讯作者：
Barsh GS
影响因子：
30.8
作者：
Alkan, Can;Kidd, Jeffrey M.;Marques-Bonet, Tomas;Aksay, Gozde;Antonacci, Francesca;Hormozdiari, Fereydoun;Kitzman, Jacob O.;Baker, Carl;Malig, Maika;Mutlu, Onur;Sahinalp, S. Cenk;Gibbs, Richard A.;Eichler, Evan E.
通讯作者：
Eichler, Evan E.
影响因子：
10.7
作者：
Lipson M;Loh PR;Levin A;Reich D;Patterson N;Berger B
通讯作者：
Berger B