Isolation and characterization of dendrimers with precise numbers of functional groups.
Isolation and characterization of dendrimers with precise numbers of functional groups.
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DOI：
10.1002/chem.201001175
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发表时间：
2010-09-17
影响因子：
4.3
通讯作者：
Holl, Mark M. Banaszak
中科院分区：
文献类型：
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作者：
Mullen, Douglas G.;Borgmeier, Emilee L.;Desai, Ankur M.;van Dongen, Mallory A.;Barash, Mark;Cheng, Xue-min;Baker, James R., Jr.;Holl, Mark M. Banaszak
功能化配体共轭纳米颗粒的研究得到了广泛的关注。这些材料的应用包括纳米级结构的构建块，传感和检测的[1]材料，靶向递送的[2]平台，成像和诊断系统，[4]和生物结构探针这些系统的一个具有挑战性的特征是每个粒子的配体的不均匀分布。对于报告的绝大多数系统，这些分布没有被描述，也没有被纳入设计参数。这种异质性的含义是双重的：首先，含有许多配体/颗粒比例的混合物使研究组成-活性关系的研究变得复杂；其次，由于纳米颗粒制备和反应动力学的不一致性，生产配体/颗粒比例分布一致的材料是有问题的。精确控制每个颗粒配体数量的新方法有可能显著提高功能功效，批量重现性，并增强探测活性与颗粒共轭配体数量之间关系的能力。在使用金纳米颗粒精确控制材料方面取得了重大进展。文献中存在许多策略来合成和/或分离具有单一官能团[6]的毫克数量的金纳米颗粒，并且纯度高达95%。含有0-5共轭配体的金纳米颗粒也已通过凝胶电泳或离子交换色谱分离到亚毫克的量
Substantial attention has been devoted to nanoparticles conjugated with functional ligands. Application of these materials has included building blocks for nano-scale structures,[1] materials for sensing and detection,[2] platforms for targeted delivery,[3] imaging and diagnostic systems,[4] and probes of biological structure.[5] One of the challenging features of these systems is the heterogeneous distribution of ligands per particle. For the vast majority of systems reported, these distributions are not characterized nor are they incorporated in design parameters. The implications of this heterogeneity are two-fold: First, mixtures containing many ligand/particle ratios make studies that investigate composition–activity relationships complex; second, production of materials with a consistent distribution of ligand/particle ratios is problematic because of inconsistencies in the nanoparticle preparations and reaction kinetics. New methods that exhibit precise control over the number of ligands per particle have the potential for dramatically improved functional efficacy, batch reproducibility, and an enhanced ability to probe the relationship between activity and the number of ligands conjugated to a particle.Significant progress has been made towards precisely controlled materials using gold nanoparticles. A number of strategies exist in the literature to synthesize and/or isolate milligram quantities of gold nanoparticles with a single functional group [6] and up to 95% purity has been achieved. Gold nanoparticles with 0–5 conjugated ligands have also been isolated in sub milligram quantities using either gel electrophoresis or ion-exchange chromatography.[7]
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影响因子：
17.1
作者：
Mullen DG;Fang M;Desai A;Baker JR;Orr BG;Banaszak Holl MM
通讯作者：
Banaszak Holl MM
影响因子：
10.8
作者：
Zanchet, D;Micheel, CM;Alivisatos, AP
通讯作者：
Alivisatos, AP
影响因子：
4.7
作者：
Mullen, Douglas G.;Desai, Ankur M.;Holl, Mark M. Banaszak
通讯作者：
Holl, Mark M. Banaszak
影响因子：
17.1
作者：
Landmark, Kevin J.;DiMaggio, Stassi;Orr, Bradford G.
通讯作者：
Orr, Bradford G.
影响因子：
38.3
作者：
通讯作者：
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