Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism.
Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism.
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DOI：
10.1016/j.imlet.2014.05.008
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发表时间：
2014-12
影响因子：
4.4
通讯作者：
Kaetzel, Charlotte S.
中科院分区：
文献类型：
--
作者：
Kaetzel, Charlotte S.
关键词：
肠道分泌的IgA （SIgA）抗体形成抗原特异性免疫防御的第一道防线，阻止病原体和共生微生物进入体内。SIgA通过聚合免疫球蛋白受体（pIgR）转运到外部分泌物中。有证据表明，肠道微生物群调节SIgA和pIgR的产生，它们共同调节微生物群的组成和活性。肠道黏液层中的SIgA有助于维持微生物群和上皮表面之间的空间隔离，而不影响微生物的代谢活性。微生物群落成员释放的产物通过激活宿主上皮细胞和免疫细胞上的模式识别受体来促进SIgA和pIgR的产生。母乳中的母体SIgA为新生哺乳动物提供保护，直到发育中的肠道免疫系统开始产生自己的SIgA。siga - pigr -微生物三联体的破坏会增加肠道感染性、过敏性和炎症性疾病的风险。
Secretory IgA (SIgA) antibodies in the intestinal tract form the first line of antigen-specific immune defense, preventing access of pathogens as well as commensal microbes to the body proper. SIgA is transported into external secretions by the polymeric immunoglobulin receptor (pIgR). Evidence is reported here that the gut microbiota regulates production of SIgA and pIgR, which act together to regulate the composition and activity of the microbiota. SIgA in the intestinal mucus layer helps to maintain spatial segregation between the microbiota and the epithelial surface without compromising the metabolic activity of the microbes. Products shed by members of the microbial community promote production of SIgA and pIgR by activating pattern recognition receptors on host epithelial and immune cells. Maternal SIgA in breast milk provides protection to newborn mammals until the developing intestinal immune system begins to produce its own SIgA. Disruption of the SIgA-pIgR-microbial triad can increase the risk of infectious, allergic andinflammatory diseases of the intestine.
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影响因子：
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