Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.
Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.
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DOI：
10.1038/s41593-023-01475-5
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发表时间：
2023-12
影响因子：
25
通讯作者：
Lin, Dayu
中科院分区：
文献类型：
--
作者：
Lischinsky, Julieta E.;Yin, Luping;Shi, Chenxi;Prakash, Nandkishore;Burke, Jared;Shekaran, Govind;Grba, Maria;Corbin, Joshua G.;Lin, Dayu
社会行为是天生的，并受到专用的神经元电路的支持，但是这些电路的分子身份以及它们如何建立和塑造经验，我们在这里尚不清楚。雄性小鼠的社会行为的反应模式和功能。专门处理男性同种提示，对成年人间的侵略性至关重要MeadBX1细胞完全显示出差异性的解剖和功能连接。级别和基于谱系的电路组织，通过该组织，细胞的胚胎转录因子轮廓决定了其成年期间其社会信息表示和行为相关性。
作者描述了来自单独的胚胎谱系的两个转录定义的杏仁核种群的连通性，响应概况和行为作用，并展示了一个人群的反应如何随社会经验而变化。
Social behaviors are innate and supported by dedicated neural circuits, but the molecular identities of these circuits and how they are established developmentally and shaped by experience remain unclear. Here we show that medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages have distinct response patterns and functions in social behavior in male mice. MeA cells expressing the transcription factor Foxp2 (MeAFoxp2) are specialized for processing male conspecific cues and are essential for adult inter-male aggression. By contrast, MeA cells derived from the Dbx1 lineage (MeADbx1) respond broadly to social cues, respond strongly during ejaculation and are not essential for male aggression. Furthermore, MeAFoxp2 and MeADbx1 cells show differential anatomical and functional connectivity. Altogether, our results suggest a developmentally hardwired aggression circuit at the MeA level and a lineage-based circuit organization by which a cell’s embryonic transcription factor profile determines its social information representation and behavioral relevance during adulthood. The authors describe the connectivity, response profile and behavioral roles of two transcriptionally defined amygdala populations from separate embryonic lineages and show how responses of one population change with social experience.
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