Genetic Variations of Vitamin A-Absorption and Storage-Related Genes, and Their Potential Contribution to Vitamin A Deficiency Risks Among Different Ethnic Groups.
Genetic Variations of Vitamin A-Absorption and Storage-Related Genes, and Their Potential Contribution to Vitamin A Deficiency Risks Among Different Ethnic Groups.
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DOI：
10.3389/fnut.2022.861619
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发表时间：
2022
影响因子：
5
通讯作者：
Tomita, Meika
中科院分区：
文献类型：
--
作者：
Suzuki, Masako;Tomita, Meika
维生素A是一种必需的脂溶性微量营养素，在体内起着关键作用，例如调节视力，免疫反应和正常发育。维生素A缺乏症（VAD）是干眼症的主要原因，并增加了感染性疾病的死亡风险。产前暴露于VAD也与以后生活中的疾病风险有关。近几十年来，VAD的总体患病率显著下降;然而，在许多低收入和中等收入国家，甚至在高收入国家的特定族裔/种族群体中，VAD的发病率仍然很高。虽然当饮食摄入量不足以满足需求时会发生VAD，但在粮食不安全和VAD之间建立了强有力的联系，维生素A补充剂是治疗VAD的主要解决方案，据报道，遗传因素也会影响血清维生素A水平。在这篇综述中，我们讨论了与维生素A状态和维生素A生物活性相关基因相关的遗传变异，特别是那些与小肠中维生素的摄取及其在肝脏中的储存相关的基因，以及它们对不同种族人群中维生素A缺乏风险的潜在贡献。
Vitamin A, an essential fat-soluble micronutrient, plays a critical role in the body, by regulating vision, immune responses, and normal development, for instance. Vitamin A deficiency (VAD) is a major cause of xerophthalmia and increases the risk of death from infectious diseases. It is also emerging that prenatal exposure to VAD is associated with disease risks later in life. The overall prevalence of VAD has significantly declined over recent decades; however, the rate of VAD is still high in many low- and mid-income countries and even in high-income countries among specific ethnic/race groups. While VAD occurs when dietary intake is insufficient to meet demands, establishing a strong association between food insecurity and VAD, and vitamin A supplementation is the primary solution to treat VAD, genetic contributions have also been reported to effect serum vitamin A levels. In this review, we discuss genetic variations associated with vitamin A status and vitamin A bioactivity-associated genes, specifically those linked to uptake of the vitamin in the small intestine and its storage in the liver, as well as their potential contribution to vitamin A deficiency risks among different ethnic groups.
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影响因子：
6.5
作者：
Behar DM;Basel-Vanagaite L;Glaser F;Kaplan M;Tzur S;Magal N;Eidlitz-Markus T;Haimi-Cohen Y;Sarig G;Bormans C;Shohat M;Zeharia A
通讯作者：
Zeharia A
影响因子：
56.9
作者：
BLOMHOFF, R;GREEN, MH;NORUM, KR
通讯作者：
NORUM, KR
DOI：
10.1080/10409238.2020.1768207
发表时间：
2020-04
影响因子：
6.5
作者：
Blaner WS;Brun PJ;Calderon RM;Golczak M
通讯作者：
Golczak M
DOI：
10.1073/pnas.79.23.7326
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BLOMHOFF, R;HELGERUD, P;NORUM, KR
通讯作者：
NORUM, KR
DOI：
10.1073/pnas.82.14.4707
发表时间：
1985-01-01
影响因子：
11.1
作者：
CROW, JA;ONG, DE
通讯作者：
ONG, DE