A pilot study of an acupuncture protocol to improve visual function in retinitis pigmentosa patients.
A pilot study of an acupuncture protocol to improve visual function in retinitis pigmentosa patients.
复制标题
DOI：
10.1111/cxo.12117
复制
发表时间：
2014-05
影响因子：
1.9
通讯作者：
Dagnelie G
中科院分区：
文献类型：
--
作者：
Bittner AK;Gould JM;Rosenfarb A;Rozanski C;Dagnelie G
视网膜色素变性患者有动力尝试补充或综合治疗，以减缓疾病进展。基础科学、临床研究和视网膜色素变性患者的自我报告支持针灸可能改善视功能的假设。一项前瞻性、病例系列、试点研究招募了12名在学术医疗中心接受治疗的RP成人患者，该患者采用标准化方案，在两周内进行10次半小时的治疗，将前额和眼睛下方的电针与身体针灸相结合。治疗前和治疗后测试包括早期治疗糖尿病视网膜病变研究视力（VA）、Pelli-Robson对比敏感度（CS）、Goldmann视野和暗适应全视野刺激阈值（FST）（n = 9）。对最后两名受试者进行了暗视敏感度测试仪-1（SST-1）暗适应检查。12名受试者中有6名在治疗后有可测量的显著视功能改善。在9名接受FST测试的受试者中，有3名在针刺后1周双眼有10.3至17.5 dB（即13至53倍）的显著改善，并维持至少10至12个月，这远远超出了先前在视网膜色素变性中发现的典型的重测变异性（95%CI：3-3.5 dB）。SST-1暗适应在两名受试者中平均缩短了48.5%（范围为36%至62%，范围为10至30 dB），这超出了先前在视网膜色素变性患者和正常人中确定的小于30%的典型变异系数。五名受试者中有四名在夜间或黑暗环境中的视觉主观改善。1例受试者VA改善0.2 logMAR;另1例受试者改善0.55 logCS。另一名受试者的戈德曼视野改善了20%以上。针灸方案完成，所有人都耐受良好，没有不良事件或视力丧失。如果由训练有素的针灸师进行，针灸的风险最小，并且可能对视网膜色素变性患者的残余视觉功能，特别是暗视敏感性有显著的，可测量的益处，这在以前没有研究过。这些初步研究结果支持了未来对潜在机制进行对照研究的必要性。
Patients with retinitis pigmentosa are motivated to try complementary or integrative therapies to slow disease progression. Basic science, clinical research and retinitis pigmentosa patients' self-reports support the hypothesis that acupuncture may improve visual function. A prospective, case series, pilot study enrolled 12 adult patients with RP treated at an academic medical centre with a standardised protocol that combined electroacupuncture to the forehead and below the eyes and acupuncture to the body, at 10 half-hour sessions over two weeks. Pre- and post-treatment tests included Early Treatment Diabetic Retinopathy Study visual acuity (VA), Pelli-Robson contrast sensitivity (CS), Goldmann visual fields, and dark-adapted full-field stimulus threshold (FST)(n = 9). Scotopic Sensitivity Tester-1 (SST-1) dark-adaptometry was performed on the last two subjects. Six of 12 subjects had measurable, significant visual function improvements after treatment. Three of nine subjects tested with the FST had a significant 10.3 to 17.5 dB (that is, 13- to 53-fold) improvement in both eyes at one week after acupuncture, maintained for at least 10 to 12 months, which was well outside typical test-retest variability (95% CI: 3–3.5 dB) previously found in retinitis pigmentosa. SST-1 dark-adaptation was shortened in both subjects tested on average by 48.5 per cent at one week (range 36 to 62 per cent across 10 to 30 dB), which was outside typical coefficients of variation of less than 30 per cent previously determined in patients with retinitis pigmentosa and normals. Four of the five subjects with psychophysically measured scotopic sensitivity improvements reported subjective improvements in vision at night or in dark environments. One subject had 0.2 logMAR improvement in VA; another had 0.55 logCS improvement. Another subject developed more than 20 per cent improvement in the area of the Goldmann visual fields. The acupuncture protocol was completed and well tolerated by all, without adverse events or visual loss. Acupuncture entails minimal risk, if administered by a well-trained acupuncturist and may have significant, measurable benefits on residual visual function in patients with retinitis pigmentosa, in particular scotopic sensitivity, which had not previously been studied. These preliminary findings support the need for future controlled studies of potential mechanisms.
登录
查看更多内容
影响因子：
0.3
作者：
DABOV, S;GOUTORANOV, G;PETKOVA, N
通讯作者：
PETKOVA, N
影响因子：
1.9
作者：
Kiser, Ava K.;Dagnelie, Gislin
通讯作者：
Dagnelie, Gislin
影响因子：
2.9
作者：
Pagani, Lucia;Manni, Luigi;Aloe, Luigi
通讯作者：
Aloe, Luigi
DOI：
10.1007/s00417-011-1757-y
发表时间：
2011-12-01
影响因子：
2.7
作者：
Beutelspacher, Sven C.;Serbecic, Nermin;Jonas, Jost B.
通讯作者：
Jonas, Jost B.
影响因子：
1.9
作者：
Litscher, G
通讯作者：
Litscher, G