Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.
Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.
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DOI：
10.1016/bs.ctdb.2020.11.009
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发表时间：
2021
影响因子：
--
通讯作者：
Echeverri K
中科院分区：
文献类型：
--
作者：
Arenas Gómez CM;Echeverri K
火蜥蜴因其再生多种组织的能力而被公认。数百年来，它们一直被用于经典的发育生物学研究，因为它们的胚胎很大，可以接触到。这些动物可以再生的组织范围令人着迷，从四肢完整到大脑或心脏的一部分，这是人类所缺乏的潜力。许多有希望的研究工作正在努力破译生物体共有的分子蓝图，这些生物体天生就有能力再生不同的组织和器官。火蜥蜴是脊椎动物的一个很好的例子，它可以在功能上再生各种组织类型。在这篇综述中，我们概述了一些重要的见解，这些见解有助于理解火蜥蜴组织再生的细胞和分子机制，并讨论为什么火蜥蜴是值得研究再生生物学的模型，以及这如何有助于再生医学等研究领域在未来为人类开发治疗方法。
Salamanders are recognized for their ability to regenerate a broad range of tissues. They have also have been used for hundreds of years for classical developmental biology studies because of their large accessible embryos. The range of tissues these animals can regenerate is fascinating, from full limbs to parts of the brain or heart, a potential that is missing in humans. Many promising research efforts are working to decipher the molecular blueprints shared across the organisms that naturally have the capacity to regenerate different tissues and organs. Salamanders are an excellent example of a vertebrate that can functionally regenerate a wide range of tissue types. In this review, we outline some of the significant insights that have been made that are aiding in understanding the cellular and molecular mechanisms of tissue regeneration in salamanders and discuss why salamanders are a worthy model in which to study regenerative biology and how this may benefit research fields like regenerative medicine to develop therapies for humans in the future.
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