Evidence of subchondral bone’s effects on articular cartilage damage in OVX-OA rat
Evidence of subchondral bone’s effects on articular cartilage damage in OVX-OA rat
复制标题
软骨下骨对 OVX-OA 大鼠关节软骨损伤影响的证据
DOI：
10.1016/j.engfracmech.2020.107081
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发表时间：
2020-06
影响因子：
5.4
通讯作者：
Huijie Leng
中科院分区：
文献类型：
--
作者：
Zhenda Zhao;Qizhao Tan;Ai Jiang;Shang Sun;Zhongjun Liu;Weishi Li;Chunli Song;Huijie Leng
软骨下骨在软骨损伤中的作用越来越引起骨关节炎（OA）研究的兴趣。由于雌激素对骨代谢的显著影响，软骨下骨可能在绝经后妇女软骨损伤中起更重要的作用。然而，由于雌激素可以同时影响软骨和软骨下骨的代谢，因此，关于软骨下骨的作用仍缺乏直接证据。本研究采用OVX-OA大鼠模型。评估软骨损伤评分、力学性能及软骨下骨小梁参数。计算第9周相对于第3周所有参数的变化率，这些参数代表OVX后的变化。结果显示，股骨关节软骨下骨改变率和软骨损伤率明显低于胫骨关节软骨损伤率。两个单位的雌激素水平相同。在OVX-OA中，下段软骨损伤响应于股骨单元的下段软骨下骨改变，这证明关节软骨损伤可能直接受到软骨下骨改变引起的机械环境变化的影响。因此，在临床上，软骨下骨可能是这类OA的一个新的治疗靶点；对于关节的数值模拟，软骨下骨和软骨不应该作为两个独立的部分来建模。
The role of subchondral bone in cartilage damage attracts increasing interests in osteoarthritis (OA) research. Subchondral bone might play more important roles in cartilage damage for postmenopausal women due to estrogen’s remarkable influence on bone metabolism. However, it still lacks direct evidence on the role of subchondral bone since estrogen can influence metabolisms of cartilage and subchondral bone at the same time. This study adopted the OVX-OA rat model. Damage scores and mechanical properties of cartilage and trabecular parameters of subchondral bone were evaluated. Change ratios of all the parameters at week 9 relative to week 3 which represented alterations after OVX were calculated. The results showed that change ratios of subchondral bone and cartilage damage in femur unit were both significantly lower than those in tibia unit. The two units were under the same estrogen level. That lower cartilage damage responded to lower subchondral bone change in femur unit provided evidence that articular cartilage damage might directly be affected by mechanical environmental changes induced by subchondral bone alteration in OVX-OA. Thus, for clinics, subchondral bone might be an new treatment target for this type of OA; for numerical simulation of articular joint, subchondral bone and cartilage shouldn’t be modeled as two independent parts.
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影响因子：
3.2
作者：
Stewart HL;Kawcak CE
通讯作者：
Kawcak CE
影响因子：
7
作者：
Srikanth, VK;Fryer, JL;Jones, G
通讯作者：
Jones, G
影响因子：
2.8
作者：
Alexandersen, P.;Karsdal, M. A.;Christiansen, C.
通讯作者：
Christiansen, C.
影响因子：
13.8
作者：
Zhen, Gehua;Cao, Xu
通讯作者：
Cao, Xu
影响因子：
2.3
作者：
Rieger R;Boulocher C;Kaderli S;Hoc T
通讯作者：
Hoc T