The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis.
The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis.
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DOI：
10.3389/fvets.2018.00178
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发表时间：
2018
影响因子：
3.2
通讯作者：
Kawcak CE
中科院分区：
文献类型：
--
作者：
Stewart HL;Kawcak CE
软骨下骨在兽医物种骨软骨疾病的发病机制中起着至关重要的作用。软骨下骨具有高度适应性，能够根据关节所承受的负载应力进行建模和重塑。关节内的重复性应力损伤可导致软骨下骨内的原发性或继发性病理损伤，这已被认为有助于骨关节炎的发生和进展。诊断成像的最新进展，特别是体积成像方式，促进了软骨下骨疾病的早期识别。尽管取得了这些进步，但我们对软骨下骨的了解有限，使得这些疾病的治疗和预防具有挑战性。本报告的目的是回顾我们目前对软骨下骨及其与跨兽医物种骨关节炎的关系的理解，特别关注在马身上进行的研究。可以得出的结论是，我们目前对软骨下骨的认识正在不断进步，未来的实验、临床和病理研究将为软骨下骨及其与关节疾病的关系提供更多见解。
Subchondral bone plays a critical role in the pathogenesis of osteochondral disease across veterinary species. The subchondral bone is highly adaptable, with the ability to model and remodel in response to loading stresses experienced by the joint. Repetitive stress injuries within the joint can result in primary or secondary pathologic lesions within the subchondral bone, which have been recognized to contribute to the development and progression of osteoarthritis. Recent advances in diagnostic imaging, particularly volumetric imaging modalities have facilitated earlier identification of subchondral bone disease. Despite these advancements, limitations in our knowledge about subchondral bone makes treatment and prevention of these conditions challenging. The purpose of this report is to review our current understanding of subchondral bone and its relationship to osteoarthritis across veterinary species, with a specific focus in the research that has been performed in horses. It can be concluded that our current understanding of subchondral bone is advancing, and future experimental, clinical and pathologic studies will provide additional insight about subchondral bone and its relationship to joint disease.
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DOI：
10.2174/1568014024606539
发表时间：
2002-04-01
期刊：
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents
影响因子：
--
作者：
Maksymowych, Walter P.
通讯作者：
Maksymowych, Walter P.
影响因子：
7
作者：
McIlwraith, C. W.;Frisbie, D. D.;Cruz, A.
通讯作者：
Cruz, A.
影响因子：
--
作者：
Hunter, David J.;Zhang, Yuqing;Felson, David T.
通讯作者：
Felson, David T.
影响因子：
1
作者：
Kawcak, CE;McIlwraith, CW;Steyn, PS
通讯作者：
Steyn, PS
影响因子：
2.2
作者：
Lajeunesse, D;Massicotte, F;Martel-Pelletier, J
通讯作者：
Martel-Pelletier, J