Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.
Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.
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DOI：
10.1109/ojemb.2020.3026234
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发表时间：
2020
影响因子：
5.8
通讯作者：
Weinberg IN
中科院分区：
文献类型：
--
作者：
Mair LO;Hale O;Jafari S;Chen C;Udalov O;Probst R;Baum I;Hevaganinge A;Yi Wang E;Rodriguez OC;Albanese C;Fricke ST;Weinberg IN
目标：开发一种微米级的装置，可以作为基于MRI的报告SARS-CoV-2病毒的存在。方法：通过模板引导合成构建铁棒微器件，并将其悬浮在磷酸盐缓冲盐水（PBS）中。将热灭活的SARS-CoV-2病毒添加到样本中，并用低场MRI成像。结果：微器械和病毒的MRI显示，在低浓度病毒下信号强度降低，在较高浓度下恢复。电子显微照片表明，MRI强度降低可能是由于铁微器件引起的局部磁不均匀性对水质子的浓度依赖性屏蔽。结论：这封信中提出的初步结果为进一步研究探索磁性微器件在评估SARS-CoV-2病毒的存在和浓度方面的潜在诊断作用提供了理由。
Goal: To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus. Methods: Iron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the samples and imaged with low-field MRI. Results: MRI of microdevices and viruses showed decreased signal intensity at low concentrations of viruses that recovered at higher concentrations. Electron micrographs suggest that reduced MRI intensity may be due to concentration-dependent shielding of water protons from local magnetic inhomogeneities caused by the iron microdevices. Conclusions: The preliminary results presented in this letter provide justification for further studies exploring the potential diagnostic role of magnetic microdevices in assessing the presence and concentration of SARS-CoV-2 viruses.
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