Sharing of identical idiotypic determinants among the monoclonal IgG, IgA and IgM in a single individual.
Sharing of identical idiotypic determinants among the monoclonal IgG, IgA and IgM in a single individual.
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单个个体的单克隆 IgG、IgA 和 IgM 共享相同的独特型决定簇。
DOI：
10.1016/0161-5890(80)90100-5
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发表时间：
1980
影响因子：
3.6
通讯作者：
Fair,DS
中科院分区：
文献类型：
--
作者：
Krueger,RG;Knowlton,DR;Kyle,RA;Fair,DS
The monoclonal IgM-κ and IgA-κ proteins from the serum of patient CM were initially shown to share identical idiotypic determinants (Fairet al., 1976). It was also shown that a portion of the IgG fraction from this patient's serum also contained the reacting idiotypic component. In this report we describe the purification to homogeneity of the IgG monoclonal protein from a later serum sample and show that this isolated IgG monoclonal protein shares identical idiotypic determinants with both the monoclonal IgM and IgA proteins. Our conclusions were based on four separate double antibody competitive equilibrium radioimmunoassays. Sequential changes in the levels of both IgG and IgA over a period of 75 months indicated that these two paraproteins fluctuated in parallel to one another during this period of time and were not significantly influenced by Chlorambucil therapy. Previous immunofluorescent data and the establishment of the structural identities of IgG to IgM and IgA suggest that both pathways of immunoglobulin differentiation (i.e. IgM → IgA and IgM → IgG) may be occurring in patient CM. The differences in the expression of these classes of immunoglobulin observed over the 75-month period may reflect the gradual maturation of these developmental pathways of antibody forming cells.
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影响因子：
15.3
作者：
Rudders, R A;Ross, R
通讯作者：
Ross, R
影响因子：
--
作者：
Natvig, J B;Kunkel, H G
通讯作者：
Kunkel, H G
人淋巴细胞上的膜结合 IgD，特别涉及免疫缺陷和免疫增殖性疾病
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8.7
作者：
J. Preud’homme;J. Brouet;M. Seligmann
通讯作者：
M. Seligmann
从抗 IG 诱导的免疫抑制中恢复：对 Ig 分泌细胞发育模型的影响。
影响因子：
4.4
作者：
D. D. Manning
通讯作者：
D. D. Manning
在鸡免疫球蛋白生成系统的个体发育过程中，IgM 形成细胞是 IgA 生成细胞的直接前体。
影响因子：
4.4
作者：
Louis N. Martin;G. Leslie
通讯作者：
G. Leslie