The Compromised Intestinal Barrier Induced by Mycotoxins.
The Compromised Intestinal Barrier Induced by Mycotoxins.
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DOI：
10.3390/toxins12100619
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发表时间：
2020-09-28
期刊：
影响因子：
4.2
通讯作者：
Zheng N
中科院分区：
文献类型：
--
作者：
Gao Y;Meng L;Liu H;Wang J;Zheng N
真菌毒素是存在于人类食品和动物饲料中的真菌代谢物，可能威胁人类和动物的健康。肠道被认为是抵御这些外部污染物的第一道屏障，它由相互关联的物理、化学、免疫和微生物屏障组成。在此背景下，基于体外、离体和体内模型，我们总结了由各种真菌毒素引起的肠道屏障问题的文献，并回顾了与肠道完整性破坏（物理屏障）、黏液层变薄（化学屏障）、炎症因子失衡（免疫屏障）和细菌稳态失调（微生物屏障）相关的事件。此外，我们还提供了脱氧雪腐菌醇（一种与肠道功能障碍有关的主要真菌毒素）和其他真菌毒素（包括黄曲霉毒素和赭曲霉毒素a）引起的其他肠道不良反应的重要信息。此外，真菌毒素引起的肠道紊乱也可能导致霉菌中毒，包括人类慢性肠道炎症性疾病。因此，我们对真菌毒素引起的肠道屏障受损有了清晰的认识，以期有可能开发出预防和治疗真菌中毒的创新策略。此外，由于真菌毒素之间的组合相互作用增加，我们在这篇综述中探讨了多种真菌毒素的相互作用。
Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially threatening human and animal health. The intestine is considered as the first barrier against these external contaminants, and it consists of interconnected physical, chemical, immunological, and microbial barriers. In this context, based on in vitro, ex vivo, and in vivo models, we summarize the literature for compromised intestinal barrier issues caused by various mycotoxins, and we reviewed events related to disrupted intestinal integrity (physical barrier), thinned mucus layer (chemical barrier), imbalanced inflammatory factors (immunological barrier), and dysfunctional bacterial homeostasis (microbial barrier). We also provide important information on deoxynivalenol, a leading mycotoxin implicated in intestinal dysfunction, and other adverse intestinal effects induced by other mycotoxins, including aflatoxins and ochratoxin A. In addition, intestinal perturbations caused by mycotoxins may also contribute to the development of mycotoxicosis, including human chronic intestinal inflammatory diseases. Therefore, we provide a clear understanding of compromised intestinal barrier induced by mycotoxins, with a view to potentially develop innovative strategies to prevent and treat mycotoxicosis. In addition, because of increased combinatorial interactions between mycotoxins, we explore the interactive effects of multiple mycotoxins in this review.
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影响因子：
6.1
作者：
Akbari P;Braber S;Varasteh S;Alizadeh A;Garssen J;Fink-Gremmels J
通讯作者：
Fink-Gremmels J
影响因子：
4.3
作者：
Abia, Wilfred A.;Warth, Benedikt;Moundipa, Paul F.
通讯作者：
Moundipa, Paul F.
影响因子：
3
作者：
Akinrinmade, Fadeyemi Joseph;Akinrinde, Akinleye Stephen;Amid, Adetayo
通讯作者：
Amid, Adetayo
影响因子：
3.2
作者：
Cano-Sancho, G.;Gonzalez-Arias, C. A.;Fernandez-Cruz, M. L.
通讯作者：
Fernandez-Cruz, M. L.
影响因子：
4.3
作者：
Broekaert, Nathan;Devreese, Mathias;Croubels, Siska
通讯作者：
Croubels, Siska