The development of a cognitive rehabilitation task for mice.
The development of a cognitive rehabilitation task for mice.
复制标题
针对小鼠的认知康复任务的发展。
DOI：
10.1016/j.nlm.2020.107296
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发表时间：
2020-11
影响因子：
2.7
通讯作者：
Sims-Robinson C
中科院分区：
文献类型：
--
作者：
Williams A;Lowry T;Sims-Robinson C
肥胖、神经退行性疾病和损伤都可能导致认知缺陷，通过实施认知康复可以在临床上得到改善。由于缺乏有效的小鼠认知康复工具，我们重新设计了一个用于检测问题解决缺陷的认知任务，以开发小鼠认知康复范式。在这项研究中，我们开发了一个修改版本的拼图盒任务，通过暴露B6小鼠的各种障碍物和评估的逃避lavelance。然后，我们组合障碍，以便为解决问题的任务创建一个“复杂障碍”。我们确定我们的任务在不同的小鼠队列中是可重复的。此外，通过重复，小鼠表现出表现的改善，这通过较短的逃避潜伏期和维持这种表现改善的能力而明显，这表明长期记忆。鉴于这种方法是新的，我们验证了这项任务是否可以成功地检测认知障碍小鼠模型（高脂饮食小鼠）的缺陷。我们证明，高脂肪饮食小鼠有更长的逃避lavelets时，暴露于复杂的障碍相比，标准饮食对照小鼠。综上所述，这些数据表明，益智盒是一个有效的任务，认知康复小鼠。
Obesity, neurodegenerative diseases, and injury can all lead to cognitive deficits, which can be improved clinically with the implementation of cognitive rehabilitation. Due to a lack of effective cognitive rehabilitation tools in mice, we re-designed a cognitive task utilized to detect problem-solving deficits, to develop a cognitive rehabilitation paradigm for mice. In this study, we developed a modified version of the Puzzle Box task by exposing B6 mice to a variety of obstacles and assessing the escape latencies. We then combined obstacles in order to create a “complex obstacle” for the problem-solving task. We determined that our task was reproducible in different cohorts of mice. Furthermore, with repetition the mice display an improvement in the performance, evident by a shorter escape latency and the ability to maintain this improvement in performance, indicative of long-term memory. Given that this approach is new, we validated whether this task could successfully detect deficits in a mouse model of cognitive impairment, the high-fat diet mouse. We demonstrate that high-fat diet mice have longer escape latencies when exposed to the complex obstacle compared to standard diet control mice. Taken together, these data suggest that the Puzzle Box is a valid task for cognitive rehabilitation in mice.
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影响因子：
3.7
作者：
Sims-Robinson C;Bakeman A;Bruno E;Jackson S;Glasser R;Murphy GG;Feldman EL
通讯作者：
Feldman EL
影响因子：
2
作者：
Arciniegas, David B.;Held, Kerri;Wagner, Peter
通讯作者：
Wagner, Peter
影响因子：
2.6
作者：
Galsworthy, MJ;Paya-Cano, JL;Plomin, R
通讯作者：
Plomin, R
影响因子：
5.3
作者：
Ben Abdallah, Nada M-B;Fuss, Johannes;Gass, Peter
通讯作者：
Gass, Peter
影响因子：
6.6
作者：
Wexler, BE;Bell, MD
通讯作者：
Bell, MD