Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial.
Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial.
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DOI：
10.1371/journal.pone.0094073
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Aikawa M
中科院分区：
文献类型：
--
作者：
Miyazaki T;Chiuve S;Sacks FM;Ridker PM;Libby P;Aikawa M
慢性炎症与肥胖、代谢综合征、糖尿病和动脉粥样硬化密切相关。有证据表明，免疫调节剂正五聚蛋白3（PTX 3）可以作为这些心脏代谢疾病的生物标志物，但PTX 3是否预测心血管并发症尚不清楚。我们在CARE试验中通过前瞻性、巢式、病例对照设计研究了血浆PTX 3水平与冠状动脉事件复发的相关性。在4159名患者中，他们在入组前3至20个月患有既往心肌梗死，并且总胆固醇水平<240 mg/dL，LDL胆固醇水平在115至175 mg/dL之间，我们通过高灵敏度ELISA测量了413例在5年随访期间复发性心肌梗死或冠状动脉死亡的患者的基线血浆PTX 3水平，以及366名性别和年龄匹配的对照组。复发性冠状动脉事件的病例和对照组有相似的PTX 3水平，PTX 3不能预测复发性冠状动脉事件-这一发现与该队列中的C反应蛋白（CRP）和血清淀粉样蛋白A（SAA）形成对比。然后，我们将PTX 3水平与代谢紊乱相关联。低血浆PTX 3水平与高体重指数、腰围和甘油三酯以及低HDL胆固醇相关。总体而言，PTX 3水平与代谢综合征组分的数量呈负相关。PTX 3水平也与apoCIII和组织纤溶酶原激活剂呈负相关，但与CRP无关。尽管该研究进一步将低PTX 3水平与代谢综合征相关的各种特征联系起来，但结果并不表明PTX 3可以预测MI幸存者中的复发性冠状动脉事件。
Chronic inflammation closely associates with obesity, metabolic syndrome, diabetes mellitus, and atherosclerosis. Evidence indicates that the immunomodulator pentraxin 3 (PTX3) may serve as a biomarker of these cardiometabolic disorders, but whether PTX3 predicts cardiovascular complications is unknown. We examined the association of plasma PTX3 levels with recurrent coronary events via a prospective, nested, case-control design in the CARE trial. Among 4159 patients who had a prior myocardial infarction 3 to 20 months before enrollment and also had total cholesterol levels <240 mg/dL and LDL cholesterol levels between 115 and 175 mg/dL, we measured plasma PTX3 levels at baseline by high-sensitivity ELISA in 413 cases with recurrent myocardial infarction or coronary death during a 5-year follow-up period, and in 366 sex- and age-matched controls. Cases with recurrent coronary events and controls had similar PTX3 levels, and PTX3 did not predict recurrent coronary events — a finding that contrasts with that of C-reactive protein (CRP) and serum amyloid A (SAA) in this cohort. We then associated PTX3 levels with metabolic disorders. Low plasma PTX3 levels correlated with high body-mass index, waist circumference, and triglycerides; and with low HDL cholesterol. Overall, PTX3 levels correlated inversely with the number of metabolic syndrome components. PTX3 levels also correlated inversely with apoCIII and tissue plasminogen activator, but did not associate with CRP. Although the study further links low PTX3 levels with various features associated with metabolic syndrome, the results do not indicate that PTX3 can predict recurrent coronary events among MI survivors.
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影响因子：
37.8
作者：
Peri, G;Introna, M;Latini, R
通讯作者：
Latini, R
影响因子：
6.5
作者：
Abderrahim-Ferkoune, A;Bezy, O;Amri, EZ
通讯作者：
Amri, EZ
影响因子：
15.9
作者：
Pepys, MB;Hirschfield, GM
通讯作者：
Hirschfield, GM
DOI：
10.2215/cjn.02320311
发表时间：
2011-12-01
影响因子：
9.8
作者：
Miyamoto, Tetsu;Qureshi, Abdul Rashid;Carrero, Juan Jesus
通讯作者：
Carrero, Juan Jesus
影响因子：
4.8
作者：
Dubin, Ruth;Li, Yongmei;Ix, Joachim H.;Shlipak, Michael G.;Whooley, Mary;Peralta, Carmen A.
通讯作者：
Peralta, Carmen A.