Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.
Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.
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DOI：
10.1084/jem.193.5.621
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发表时间：
2001-03-05
期刊：
影响因子：
--
通讯作者：
Nishikawa SI
中科院分区：
文献类型：
--
作者：
Honda K;Nakano H;Yoshida H;Nishikawa S;Rennert P;Ikuta K;Tamechika M;Yamaguchi K;Fukumoto T;Chiba T;Nishikawa SI
白细胞介素7受体α（IL-7 R α）或光敏素β受体（LTβR）缺陷的小鼠缺乏派尔集合淋巴结（PP）。CXC趋化因子受体5（CXCR 5）的缺乏也严重影响PP的发展。一个分子网络，涉及这三个信号通路已牵连PP器官发生，但目前仍不清楚它们是如何连接在这个过程中。我们已经证明PP器官发生起始于含有IL-7 R α+淋巴样细胞和表达非淋巴样成分的血管细胞粘附分子（VCAM）-1/细胞间粘附分子（ICAM）-1的位点。在这里，我们描述这些淋巴和非淋巴成分的趋化因子信号。淋巴细胞群表达CXCR 5，并对B淋巴细胞趋化因子（BLC）具有强烈的趋化反应。重要的是，由VCAM-1+ICAM-1+非淋巴样细胞产生的趋化因子介导淋巴样细胞的募集。此外，我们还发现这些VCAM-1+ICAM-1+细胞是间充质细胞，它们被淋巴样细胞通过LTβR激活，表达粘附分子和趋化因子。因此，PP发展的促进依赖于间充质细胞和淋巴样细胞之间的相互作用。
Mice deficient in lymphotoxin β receptor (LTβR) or interleukin 7 receptor α (IL-7Rα) lack Peyer's patches (PPs). Deficiency in CXC chemokine receptor 5 (CXCR5) also severely affects the development of PPs. A molecular network involving these three signaling pathways has been implicated in PP organogenesis, but it remains unclear how they are connected during this process. We have shown that PP organogenesis is initiated at sites containing IL-7Rα+ lymphoid cells and vascular cell adhesion molecule (VCAM)-1/intercellular adhesion molecule (ICAM)-1 expressing nonlymphoid elements. Here we characterize these lymphoid and nonlymphoid components in terms of chemokine signals. The lymphoid population expresses CXCR5 and has a strong chemotactic response to B lymphocyte chemoattractant (BLC). Importantly, chemokines produced by VCAM-1+ICAM-1+ nonlymphoid cells mediate the recruitment of lymphoid cells. Furthermore, we show that these VCAM-1+ICAM-1+ cells are mesenchymal cells that are activated by lymphoid cells through the LTβR to express adhesion molecules and chemokines. Thus, promotion of PP development relies on mutual interaction between mesenchymal and lymphoid cells.
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影响因子：
4.4
作者：
Adachi, S;Yoshida, H;Nishikawa, S
通讯作者：
Nishikawa, S
影响因子：
30.8
作者：
Headon, DJ;Overbeek, PA
通讯作者：
Overbeek, PA
影响因子：
24.5
作者：
DAVIES, MDJ;PARROTT, DMV
通讯作者：
PARROTT, DMV
影响因子：
12.4
作者：
Murphy, M;Walter, BN;Epstein, LB
通讯作者：
Epstein, LB
影响因子：
64.5
作者：
Förster, R;Schubel, A;Lipp, M
通讯作者：
Lipp, M