Validation of Peripheral Quantitative Computed Tomography-Derived Thigh Adipose Tissue Subcompartments in Young Girls Using a 3 T MRI Scanner.
Validation of Peripheral Quantitative Computed Tomography-Derived Thigh Adipose Tissue Subcompartments in Young Girls Using a 3 T MRI Scanner.
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DOI：
10.1016/j.jocd.2018.03.002
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Going SB
中科院分区：
文献类型：
--
作者：
Blew RM;Lee VR;Bea JW;Hetherington-Rauth MC;Galons JP;Altbach MI;Lohman TG;Going SB
考虑到与肌肉的更大脂肪浸润相关的负面临床意义，评估骨骼肌脂肪组织的能力是重要的。计算机断层扫描和磁共振成像（MRI）对于测量关节周围的软组织和肌肉成分是高度准确的，但有局限性。外周定量计算机断层扫描（pQCT）是研究人员发现有价值的替代方法，因为其辐射低，扫描时间快，成本相对较低。本研究旨在评估pQCT衍生的估计值的准确性，总，皮下，骨骼肌，肌间和计算的肌内脂肪组织面积，并使用金标准，3 T MRI作为标准的年轻女孩大腿中部的肌肉密度。横断面资料进行了分析，为26名健康的女孩，年龄在9至12岁。通过pQCT和3 T MRI评估大腿中部软组织组成。使用t检验、回归分析和Bland-Altman图比较pQCT和MRI测量的相应脂肪区室的平均组织面积。在MRI骨骼肌脂肪组织、肌间脂肪组织和肌内脂肪组织上回归肌肉密度，每种脂肪组织均表示为总肌肉面积的百分比。对于总脂肪组织（r2=0.98）、皮下脂肪组织（r2 = 0.95）、骨骼肌脂肪组织（r2=0.83）和肌间脂肪组织（r2=0.82），MRI和pQCT之间的相关性很高，pQCT肌肉密度与MRI骨骼肌脂肪组织（r2=0.70）和MRI肌间脂肪组织（r2=0.70）相关性良好。pQCT对总脂肪组织和皮下脂肪组织有轻微但具有统计学意义的低估，而骨骼肌脂肪组织没有观察到显著差异。pQCT估计的肌内脂肪组织和肌肉密度与MRI肌内脂肪组织弱相关。我们的结论是，pQCT是一种有效的测量技术，估计所有的脂肪亚室，除了肌内脂肪组织，为大腿中部地区的年轻/青春期女孩。
The ability to assess skeletal muscle adipose tissue is important given the negative clinical implications associated with greater fat infiltration of the muscle. Computed tomography and magnetic resonance imaging (MRI) are highly accurate for measuring appendicular soft tissue and muscle composition, but have limitations. Peripheral quantitative computed tomography (pQCT) is an alternative that investigators find valuable because of its low radiation, fast scan time, and comparatively lower costs. The present investigation sought to assess the accuracy of pQCT-derived estimates of total-, subcutaneous-, skeletal muscle-, intermuscular-, and calculated intramuscular-adipose tissue areas, and muscle density in the mid-thigh of young girls using the gold standard, 3 T MRI, as the criterion. Cross-sectional data were analyzed for 26 healthy girls aged 9 to 12 years. Mid-thigh soft tissue composition was assessed by both pQCT and 3 T MRI. Mean tissue area for corresponding adipose compartments by pQCT and MRI was compared using t-tests, regression analysis, and Bland-Altman plots. Muscle density was regressed on MRI skeletal muscle adipose tissue, intermuscular adipose tissue, and intra-muscular adipose tissue, each expressed as a percentage of total muscle area. Correlations were high between MRI and pQCT for total adipose tissue (r2=0.98), subcutaneous adipose tissue (r2=0.95), skeletal muscle adipose tissue (r2=0.83), and intermuscular adipose tissue (r2=0.82), and pQCT muscle density correlated well with both MRI skeletal muscle adipose tissue (r2=0.70) and MRI intermuscular adipose tissue (r2=0.70). There was a slight, but statistically significant underestimation by pQCT for total and subcutaneous adipose tissue, while no significant difference was observed for skeletal muscle adipose tissue. Both pQCT-estimated intramuscular adipose tissue and muscle density were weakly correlated with MRI-intramuscular adipose tissue. We conclude that pQCT is a valid measurement technique for estimating all adipose sub-compartments, except for intramuscular adipose tissue, for the mid-thigh region in young/adolescent girls.
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影响因子：
6.9
作者：
Dube, Marie-Christine;Lemieux, Simone;Weisnagel, Stanley J.
通讯作者：
Weisnagel, Stanley J.
影响因子：
1.4
作者：
Alizai, Hamza;Chang, Gregory;Regatte, Ravinder R.
通讯作者：
Regatte, Ravinder R.
影响因子：
3.2
作者：
Sherk, Vanessa D.;Bemben, Michael G.;Bemben, Debra A.
通讯作者：
Bemben, Debra A.
在受试者运动的存在下对PQCT图像质量的标准化评估：定性与定量评估。
影响因子：
4.2
作者：
Blew, Robert M.;Lee, Vinson R.;Farr, Joshua N.;Schiferl, Daniel J.;Going, Scott B.
通讯作者：
Going, Scott B.
影响因子：
4.1
作者：
Bea JW;Cussler EC;Going SB;Blew RM;Metcalfe LL;Lohman TG
通讯作者：
Lohman TG