Spatial and memory circuits in the medial entorhinal cortex.

Spatial and memory circuits in the medial entorhinal cortex.
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DOI:
10.1016/j.conb.2014.10.008
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发表时间:
2015-06
影响因子:
5.7
通讯作者:
Leutgeb JK
Leutgeb JK
中科院分区:
医学2区
文献类型:
--
作者:
Sasaki T;Leutgeb S;Leutgeb JK

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情景记忆的大容量被认为是由用于不相关记忆的不同海马细胞集合的出现所支持的,从而使干扰最小化。在大规模群体记录中,跨环境的海马表征的正交性质在海马位置细胞放电位置的完全重组中很明显。内嗅网格细胞向海马体提供输入,并且它们的放电模式在不同环境中相对彼此变化。尽管这表明改变的网格细胞放电可能会产生不同的海马群体代码,但最近的研究表明,当网格细胞放电受到损害时,会出现新的、独特的海马位置场。因此,我们建议内侧内嗅皮层内的单独电路专门用于执行空间或记忆相关的计算。
The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complete reorganization of the firing locations of hippocampal place cells. Entorhinal grid cells provide inputs to the hippocampus, and their firing patterns shift relative to each other across different environments. Although this suggests that altered grid cell firing could generate distinct hippocampal population codes, it has recently been shown that new and distinct hippocampal place fields emerge while grid cell firing is compromised. We therefore propose that separate circuits within the medial entorhinal cortex are specialized for performing either spatial or memory-related computations.
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