Notoginsenoside Fe suppresses diet induced obesity and activates paraventricular hypothalamic neurons.
Notoginsenoside Fe suppresses diet induced obesity and activates paraventricular hypothalamic neurons.
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DOI：
10.1039/c8ra07842d
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发表时间：
2019-01-09
期刊：
影响因子：
3.9
通讯作者：
Fan, Shengjie
中科院分区：
文献类型：
--
作者：
Li, Hongli;Liu, Yalei;Liu, Chuhe;Luo, Lingling;Yao, Yin;Li, Fei;Yin, Liufang;Xu, Lai;Tong, Qingchun;Huang, Cheng;Fan, Shengjie
肥胖症已成为世界范围内的一个重大公共卫生挑战。热量获取和消耗之间的能量失衡是肥胖的根本原因。三七铁是三七中的一种天然化合物，三七是一种用于治疗心血管疾病的中药。在此，我们评估了三七铁对高脂饮食诱导的C57 BL/6小鼠肥胖发展的影响。我们的研究结果表明，三七铁减少摄食量和体重，以及保护肝脏结构的完整性和正常功能。代谢笼分析表明，三七铁还促进了静息代谢率。此外，侧脑室注射（i.c.v）的铁诱导C-Fos的表达在室旁核（PVH），但不弓状核（ARC）的下丘脑。这些结果表明，铁可能通过激活下丘脑中的能量感受神经元来减轻体重。三七皂甙铁是三七中天然存在的化合物，通过激活高脂饮食诱导的肥胖小鼠PVH中C-Fos表达，显着减轻体重，促进代谢率，并抑制食物摄入。
Obesity has become a major public health challenge worldwide. Energy imbalance between calorie acquisition and consumption is the fundamental cause of obesity. Notoginsenoside Fe is a naturally occurring compound in Panax notoginseng, a herb used in the treatment of cardiovascular diseases in traditional Chinese medicine. Here, we evaluated the effect of notoginsenoside Fe on obesity development induced by high-fat diet in C57BL/6 mice. Our results demonstrated that notoginsenoside Fe decreased food intake and body weight, as well as protected liver structure integrity and normal function. Metabolic cage analysis showed that notoginsenoside Fe also promoted resting metabolic rate. In addition, intracerebroventricular (i.c.v) injection of notoginsenoside Fe induced C-Fos expression in the paraventricular nucleus (PVH) but not the arcuate nucleus (ARC) of the hypothalamus. These results suggest that Fe may reduce body weight through the activation of energy-sensing neurons in the hypothalamus. Notoginsenoside Fe, a naturally occurring compound in Panax notoginseng, significantly reduces body weight, promotes metabolic rate, and suppresses food intake through activating C-Fos expression in PVH in high-fat diet induced obese mice.
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影响因子：
4.3
作者：
Asaoka Y;Terai S;Sakaida I;Nishina H
通讯作者：
Nishina H
影响因子：
29
作者：
An JJ;Liao GY;Kinney CE;Sahibzada N;Xu B
通讯作者：
Xu B
影响因子：
8.8
作者：
Belfort-DeAguiar, Renata;Seo, Dongju
通讯作者：
Seo, Dongju
DOI：
10.1007/7854_2018_54
发表时间：
2019-01-01
期刊：
NEUROENDOCRINE REGULATION OF BEHAVIOR
影响因子：
--
作者：
Klockars, Anica;Levine, Allen S.;Olszewski, Pawel K.
通讯作者：
Olszewski, Pawel K.
DOI：
10.19540/j.cnki.cjcmm.20170121.014
发表时间：
2017-03-01
期刊：
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
影响因子：
--
作者：
Hou, Qian-Ling;Wang, Yan;Wang, Sha-Li
通讯作者：
Wang, Sha-Li