Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media.
Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media.
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DOI：
10.1086/599833
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发表时间：
2009-07-15
期刊：
影响因子：
--
通讯作者：
Chonmaitree T
中科院分区：
文献类型：
--
作者：
Revai K;Patel JA;Grady JJ;Nair S;Matalon R;Chonmaitree T
我们之前报道过肿瘤坏死因子 α (TNFα)−308 和白细胞介素 6 (IL-6)−174 多态性与病史中耳炎易感性之间的关联。急性中耳炎 (AOM) 最常见的是上呼吸道感染 (URI) 的并发症；目前尚不清楚为什么有些孩子在 URI 后出现 AOM，而另一些孩子却没有。我们的目标是前瞻性评估 TNFα−308 和 IL-6−174 多态性与 URI 和 URI 后 AOM 发展的关联。 6-35 个月的儿童。前瞻性跟踪 URI 和 AOM 的发生情况。收集血液或颊粘膜样本进行DNA提取以确定细胞因子基因型。采用主动和被动监测来捕获一年随访期间的所有 URI 发作，以研究 URI 后 AOM 的发生率。使用 SAS 和一般估计方程模型分析数据。 242 名儿童接受了超过 2689 个患者月的随访，并进行了 DNA 基因分型；发生 1235 例 URI 发作，其中 392 例（32%）并发 AOM。具有 IL-6−174 多态性的儿童在研究期间对 URI 的易感性较高 (IDR:1.24)，并且更有可能满足既定的中耳炎易感性标准 (p<0.01)。 TNFα−308 多态性的存在与 URI 发作后 AOM 风险增加相关（OR：1.43）。 TNFα−308 和 IL-6−174 基因型与症状性 URI 和 URI 后 AOM 的风险增加相关。未来的研究可能旨在仔细研究这些遗传多态性与可改变的环境风险因素的相互作用。
We previously reported an association between tumor necrosis factor alpha (TNFα)−308 and interleukin 6 (IL-6)−174 polymorphisms and otitis susceptibility by history. Acute otitis media (AOM) occurs most commonly as a complication of upper respiratory tract infection (URI); it is not clear why some children develop AOM after URI and others do not. Our objective was to prospectively evaluate the association of TNFα−308 and IL-6−174 polymorphisms with URI and AOM development after URI. Children 6–35 mos. were prospectively followed for occurrences of URI and AOM. Blood or buccal mucosa samples were collected for DNA extraction to determine cytokine genotypes. Active and passive surveillance was used to capture all URI episodes during the one-year follow-up period in order to study the rate of AOM following URI. Data were analyzed using SAS and general estimating equations modeling. 242 children were followed over 2689 patient months and had DNA genotyped; 1235 URI episodes occurred, 392 (32%) were complicated by AOM. Children who had IL-6−174 polymorphism had a higher susceptibility to URI during the study period (IDR:1.24) and were more likely to meet established otitis susceptibility criteria (p<0.01). Presence of TNFα−308 polymorphism was associated with increased risk for AOM following an episode of URI (OR:1.43). TNFα−308 and IL-6−174 genotypes are associated with increased risk for symptomatic URI and AOM following URI. Future studies may be designed to carefully look at the interaction of these genetic polymorphisms with modifiable environmental risk factors.
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影响因子：
5.1
作者：
MISTCHENKO, AS;DIEZ, RA;GRINSTEIN, S
通讯作者：
GRINSTEIN, S
影响因子：
120.7
作者：
Mira, JP;Cariou, A;Dhainaut, JF
通讯作者：
Dhainaut, JF
影响因子：
3.6
作者：
Allen, RD
通讯作者：
Allen, RD
影响因子：
6.4
作者：
TEELE, DW;KLEIN, JO;ROSNER, B
通讯作者：
ROSNER, B
影响因子：
6.4
作者：
NOAH, TL;HENDERSON, FW;BECKER, S
通讯作者：
BECKER, S