State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.
State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.
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DOI：
10.1111/jgs.15353
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发表时间：
2018-04
影响因子：
6.3
通讯作者：
Steffens DC
中科院分区：
文献类型：
--
作者：
Manning KJ;Steffens DC
老年人的重度抑郁症或晚年抑郁症（LLD）是一种常见的使人衰弱的精神疾病，增加了发病率和死亡率的风险。虽然与LLD相关的有害后果突出了促进及时诊断和治疗的重要性，但患有LLD的老年人往往治疗不足或治疗不成功。最新的治疗进展表明，针对执行功能障碍和神经质的干预措施，与老年人对抗抑郁药反应不良相关的结构，在治疗LLD抑郁症方面是成功的。具体的行为干预（计算机认知训练，正念冥想和有氧运动）似乎可以改善抑郁症状，改善执行功能障碍和神经质。然而，我们并不完全了解这些治疗可能起作用的机制。本文综述了最近关于LLD中执行功能障碍和神经质的神经网络变化及其与临床结局（例如，治疗反应、认知功能）。
Major depression in older adults, or late-life depression (LLD), is a common and debilitating psychiatric disorder that increases the risk of morbidity and mortality. Whereas the detrimental consequences associated with LLD highlight the importance of facilitating timely diagnosis and treatment, older adults with LLD are often inadequately or unsuccessfully treated. The latest treatment developments suggest that interventions targeting executive dysfunction and neuroticism, constructs associated with poor response to antidepressants in older adults, are successful in treating depression in LLD. Specific behavioral interventions (computerized cognitive training, mindfulness meditation, and aerobic exercise) appear to improve depressive symptoms and ameliorate executive dysfunction and neuroticism. Yet, we do not fully understand the mechanisms by which these treatments may work. The current paper reviews recent research on neural network changes underlying executive dysfunction and neuroticism in LLD and their association with clinical outcomes (e.g., treatment response, cognitive functioning).
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