Prenatal and childhood environmental tobacco smoke exposure and age at menarche.
Prenatal and childhood environmental tobacco smoke exposure and age at menarche.
复制标题
产前和儿童时期环境烟草烟雾暴露和初潮年龄。
DOI：
10.1111/j.1365-3016.2010.01154.x
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发表时间：
2010-11
影响因子：
2.8
通讯作者：
Terry MB
中科院分区：
文献类型：
--
作者：
Ferris JS;Flom JD;Tehranifar P;Mayne ST;Terry MB
先前的研究报告了关于初潮年龄和环境烟草烟雾暴露之间的关联的混合结果，包括产前和幼儿期;然而，很少有研究在这两个时期都有数据。本研究探讨是否暴露于产前烟草烟雾（PTS）通过母亲在怀孕期间吸烟或儿童环境烟草烟雾（ETS）与初潮年龄在多种族出生队列。通过前瞻性收集出生时和生命早期的体型和生长数据，我们进一步研究了PTS和ETS暴露与初潮年龄之间的关联是否由这些变量介导。从2001年到2006年，我们招募了262名出生于1959年到1963年之间的妇女，她们以前在国家围产期合作项目的纽约市站点登记。怀孕期间吸烟的母亲与那些不吸烟的母亲相比，更有可能是白色、更年轻、受教育程度更高、出生体重更低的婴儿。与无PTS的女儿相比，有大量PTS暴露（每天≥20支香烟）的女儿在月经初潮时的年龄较晚（>12岁vs. ≤12岁），比值比（OR）= 2.1 [95%置信区间（CI）0.9，5.0]。与无PTS和无ETS的女儿相比，仅暴露于儿童期ETS的女儿月经初潮年龄较晚，OR = 2.1 [95%CI 1.0，4.3]，暴露于PTS和ETS的女儿月经初潮年龄较晚，OR = 2.2 [95%CI 1.1，4.6]，具有统计学意义。进一步调整出生体重和出生后生长后，这些结果没有改变，表明暴露于PTS和ETS与月经初潮年龄晚，即使在考虑可能与生长的关系。
Previous studies have reported mixed results regarding the association between age at menarche and environmental tobacco smoke exposure, both prenatally and during early childhood; however, few studies have had data available during both time periods. The present study examined whether exposure to prenatal tobacco smoke (PTS) via maternal smoking during pregnancy or childhood environmental tobacco smoke (ETS) was associated with age at menarche in a multi-ethnic birth cohort. With the uniquely available prospectively collected data on body size and growth at birth and in early life, we further examined whether the association between PTS and ETS exposure and age at menarche was mediated by these variables. From 2001 to 2006, we recruited 262 women born between 1959 and 1963 who were enrolled previously in a New York City site of the National Collaborative Perinatal Project. Mothers who smoked during pregnancy vs. those who did not were more likely to be White, younger, have more education and have lower birthweight babies. Daughters with heavy PTS exposure (≥20 cigarettes per day) had a later age at menarche (>12 years vs. ≤12 years), odds ratio (OR) = 2.1 [95% confidence interval (CI) 0.9, 5.0] compared with daughters with no PTS. Daughters exposed to only childhood ETS had a later age at menarche, OR = 2.1 [95% CI 1.0, 4.3], and those exposed to PTS and ETS combined had a statistically significant later age at menarche, OR = 2.2 [95% CI 1.1, 4.6] compared with daughters with no PTS and no ETS. These results did not change after further adjustment for birthweight and postnatal growth suggesting that exposure to PTS and ETS is associated with later age at menarche even after considering possible relationships with growth.
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通讯作者：
FRENCH, KS
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