The Hammerhead Ribozyme: A Long History for a Short RNA.
The Hammerhead Ribozyme: A Long History for a Short RNA.
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DOI：
10.3390/molecules22010078
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发表时间：
2017-01-04
期刊：
影响因子：
--
通讯作者：
Cervera A
中科院分区：
文献类型：
--
作者：
de la Peña M;García-Robles I;Cervera A
小核溶核酶是一个天然存在的RNA基序家族，它以高度序列特异性的方式催化自酯交换反应。锤头核酶是这个家族中最早被报道和研究最广泛的成员。然而，尽管自发现以来进行了三十年激烈的生化和结构研究，但这种模型核酶的历史似乎远未结束。锤头核酶一直被认为是一种典型的植物小环状RNA病原体的生物怪。最近，这种核酶的许多新变体被发现存在于所有生物王国的生物体基因组中，尽管它们的确切生物学功能尚未被很好地理解。
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most extensively studied member of this family. However, and despite intense biochemical and structural research for three decades since its discovery, the history of this model ribozyme seems to be far from finished. The hammerhead ribozyme has been regarded as a biological oddity typical of small circular RNA pathogens of plants. More recently, numerous and new variations of this ribozyme have been found to inhabit the genomes of organisms from all life kingdoms, although their precise biological functions are not yet well understood.
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