Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.
Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.
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DOI：
10.1016/j.jad.2017.12.089
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发表时间：
2018-03-15
影响因子：
6.6
通讯作者：
King JA
中科院分区：
文献类型：
--
作者：
Nephew BC;Febo M;Huang W;Colon-Perez LM;Payne L;Poirier GL;Greene O;King JA
在动物和临床研究中，静息态功能连接（RSFC）功能磁共振成像技术的不断发展和完善增强了我们对压力对精神健康的不良影响的理解。本研究的目的是评估母亲的行为和静息状态功能连接（RSFC）的变化，在这些动物时，他们照顾自己的年轻的母鼠。据推测，ECSS暴露的母鼠将表达抑郁的母性关怀，并表现出类似的（相同的网络），但不同的具体变化RSFC（不同的个别核）时，他们是成年女性报告。我们已经开发了一个行为学相关的跨代模型的作用，慢性社会压力（CSS）的产后抑郁症和焦虑的病因。CSS模型的初步fMRI研究表明，早期生活暴露于CSS（ECSS）诱导长期的功能连接的变化，在成年未经生育的女性F1后代。ECSS在F1代母鼠导致抑郁症的孕产妇护理，特别是在哺乳早期，与以前的CSS研究一致，并诱导功能连接的变化与感官处理，母亲和情绪反应，记忆和奖励途径，与强大的变化在前扣带回电路。fMRI组的样本量较低，限制了统计功效。这种行为和功能神经解剖学基础现在可以用来提高我们对早期生活压力相关疾病的神经病因学的理解，并测试压力相关疾病的预防措施和治疗方法。
Continued development and refinement of resting state functional connectivity (RSFC) fMRI techniques in both animal and clinical studies has enhanced our comprehension of the adverse effects of stress on psychiatric health. The objective of the current study was to assess both maternal behavior and resting state functional connectivity (RSFC) changes in these animals when they were dams caring for their own young. It was hypothesized that ECSS exposed dams would express depressed maternal care and exhibit similar (same networks), yet different specific changes in RSFC (different individual nuclei) than reported when they were adult females. We have developed an ethologically relevant transgenerational model of the role of chronic social stress (CSS) in the etiology of postpartum depression and anxiety. Initial fMRI investigation of the CSS model indicates that early life exposure to CSS (ECSS) induces long term changes in functional connectivity in adult nulliparous female F1 offspring. ECSS in F1 dams resulted in depressed maternal care specifically during early lactation, consistent with previous CSS studies, and induced changes in functional connectivity in regions associated with sensory processing, maternal and emotional responsiveness, memory, and the reward pathway, with robust changes in anterior cingulate circuits. The sample sizes for the fMRI groups were low, limiting statistical power. This behavioral and functional neuroanatomical foundation can now be used to enhance our understanding of the neural etiology of early life stress associated disorders and test preventative measures and treatments for stress related disorders.
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影响因子：
2.9
作者：
Febo, Marcelo;Shields, Jessica;Ferris, Craig F.;King, Jean A.
通讯作者：
King, Jean A.
影响因子：
3.3
作者：
Coverdill, Alexander J.;McCarthy, Megan;Nephew, Benjamin C.
通讯作者：
Nephew, Benjamin C.
影响因子：
3.5
作者：
Febo, Marcelo;Stolberg, Tara L.;Ferris, Craig F.
通讯作者：
Ferris, Craig F.
影响因子：
4.7
作者：
Caffrey MK;Nephew BC;Febo M
通讯作者：
Febo M
影响因子：
3.2
作者：
Baker LM;Williams LM;Korgaonkar MS;Cohen RA;Heaps JM;Paul RH
通讯作者：
Paul RH