Oxytocin modulates unconditioned fear response in lactating dams: an fMRI study.
Oxytocin modulates unconditioned fear response in lactating dams: an fMRI study.
复制标题
DOI：
10.1016/j.brainres.2009.09.043
复制
发表时间：
2009-12-11
期刊：
影响因子：
2.9
通讯作者：
King, Jean A.
中科院分区：
文献类型：
--
作者：
Febo, Marcelo;Shields, Jessica;Ferris, Craig F.;King, Jean A.
关键词：
哺乳期催产素能神经传递有助于减少焦虑水平和恐惧。然而，我们对催产素在大脑中发挥作用以实现这种效果的知识，特别是对无条件恐惧刺激的知识，是不完整的。我们使用血氧水平依赖（BOLD）功能磁共振成像测试是否中央管理催产素前45-60分钟功能磁共振成像扫描改变母亲的大脑激活反应的捕食者气味（TMT，三甲基噻唑啉）。比较行为实验，检查母亲的反应，这种无条件的恐惧诱导气味进行了一个单独的队列哺乳期大鼠给予类似的治疗。行为实验证实了催产素与载体对照相比在减少冻结行为方面的有效性。我们的fMRI研究结果表明，催产素调制积极和消极的BOLD反应在几个嗅觉和前脑核。在催产素预处理大鼠的前扣带回、终纹床核和嗅周区观察到BOLD信号响应TMT的显著更大百分比增加。这些动物在乳头体、次级运动皮层、味觉皮层、前边缘前额叶皮层、眶皮层和前嗅核中也显示出BOLD的显著较大百分比下降。观察到的大脑活动模式表明，催产素增强了情绪和认知驱动的大脑区域如扣带皮层的神经处理，同时显著降低了还控制自主神经、内脏神经和骨骼运动反应的区域的活动。目前的数据有助于越来越多的文献表明，催产素通过无数的大脑区域调节情感和认知信息的整合，以促进焦虑的减少（即使是无条件刺激），同时可能促进配对，社会记忆和父母照顾。
Oxytocinergic neurotransmission during lactation contributes to reduction of anxiety levels and fear. However, our knowledge of where oxytocin acts in the brain to achieve this effect, particularly to an unconditioned fear stimulus, is incomplete. We used blood oxygenation level dependent (BOLD) fMRI to test whether central administration of oxytocin 45–60 minutes before fMRI scanning alters maternal brain activation in response to a predator scent (TMT, trimethylthiazoline). Comparison behavioral experiments that examined maternal responses to this unconditioned fear -inducing odor were carried out in a separate cohort of lactating rats given similar treatments. Behavioral experiments confirmed the effectiveness of oxytocin at reducing freezing behavior as compared to vehicle controls. Our fMRI findings indicate that oxytocin modulated both positive and negative BOLD responses across several olfactory and forebrain nuclei. Significantly greater percent increases in BOLD signal in response to TMT were observed in the anterior cingulate, bed nucleus of stria terminalis and perirhinal area of oxytocin pretreated rats. These animals also showed significantly larger percent decreases in BOLD in mammillary bodies, secondary motor cortex, gustatory cortex, prelimbic prefrontal cortex, orbital cortex, and the anterior olfactory nucleus. The observed pattern of brain activity suggests that oxytocin enhances neural processing in emotion and cognition driven brain areas such as the cingulate cortex, while dramatically reducing activity in areas also controlling autonomic, visceromotor and skeletomotor responses. The present data contribute to the growing literature suggesting the oxytocin modulate the integration of emotional and cognitive information through myriad brain regions to facilitate decreases in anxiety (even to an unconditioned stimulus) while potentially promoting pair-bonding, social memory and parental care.
登录
查看更多内容
影响因子：
5.3
作者：
Bale, TL;Davis, AM;McCarthy, MM
通讯作者：
McCarthy, MM
DOI：
10.1073/pnas.0807412105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Bosch, Oliver J.;Neumann, Inga D.
通讯作者：
Neumann, Inga D.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
1.9
作者：
FERREIRA, A;DAHLOF, LG;HANSEN, S
通讯作者：
HANSEN, S
影响因子：
3.2
作者：
Francis, DD;Champagne, FC;Meaney, MJ
通讯作者：
Meaney, MJ